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- W2094364097 abstract "LIFE-THREATENING hypersensitivity after administration of sulindac has not been reported, to our knowledge, although fatal reactions have been reported to other nonsteroidal anti-inflammatory drugs.<sup>1,2</sup>We believe the following case represents a severe hypersensitivity reaction. <h3>Report of a Case</h3> An 18-year-old man was seen with acute polyarthritis and fever on Feb 25, 1979. Investigation showed evidence of viral or bacterial infection. History and physical examination findings were consistent with rheumatoid arthritis. Rheumatoid factor was positive at 1:320 and antinuclear antibodies positive at 1:80 with a nucleolar pattern. The ESR was 65 mm/hr. A tentative diagnosis of rheumatoid arthritis was made, and treatment was started with a combination of aspirin, magnesium hydroxide, and dried aluminum hydroxide gel (Ascriptin). Although his joint disease improved and fever resolved, epigastric pain developed that was unrelieved by antacids. On June 11, Ascriptin therapy was discontinued, and treatment was started with sulindac, 150 mg twice a" @default.
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- W2094364097 date "1980-07-18" @default.
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- W2094364097 title "Life-threatening Hypersensitivity to Sulindac" @default.
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- W2094364097 doi "https://doi.org/10.1001/jama.1980.03310030045026" @default.
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