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• W2094365861 abstract "Rabies virus infection in man induces a series of clinical symptoms, some suggesting involvement of the central serotonergic system. The results of the present study show that, 5 days after rabies virus infection in rat, the total reversible high-affinity binding of [3H]5-HT in the hippocampus is not affected, suggesting that 5-HT1A binding is not altered. 5-HT1B sites identified by [125I]cyanopindolol binding are not affected in the cortex 3 and 5 days after the infection. Accordingly, the cellular inhibitory effect of trifluoromethylphenylpiperazine (TFMPP) on the [3H]acetylcholine-evoked release, presumably related to 5-HT1B receptor activity, is not modified 3 days after infection. In contrast, [3H]5-HT binding determined in the presence of drugs masking 5-HT1A, 5-HT1B and 5-HT1C receptors, is markedly (50%) reduced 3 days after the viral infection. These results suggest that 5-HT1D-like receptor subtypes may be affected specifically and at an early stage after rabies viral infection." @default.
• W2094365861 created "2016-06-24" @default.
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• W2094365861 date "1993-04-01" @default.
• W2094365861 modified "2023-09-23" @default.
• W2094365861 title "Rabies virus selectively alters 5-HT1 receptors subtypes in rat brain" @default.
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• W2094365861 doi "https://doi.org/10.1016/0922-4106(93)90120-x" @default.
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