Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094388623> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2094388623 endingPage "2455" @default.
- W2094388623 startingPage "2450" @default.
- W2094388623 abstract "A recently developed deoxythymidine kinase assay, utilizing iodine-125-iodo-deoxyuridine as substrate and capable of detecting enzyme activity in serum from healthy humans, was used in an investigation of sera from 55 untreated patients with chronic lymphocytic leukemia (CLL). When confined to the study, the patients were classified as having progressive or indolent disease and according to Rai stage. The results showed a significant correlation between serum deoxythymidine kinase activity (S-TK) and disease status, i.e., higher values were found in patients with progressive disease, compared to those with indolent disease. S-TK also correlated with Rai stage. S-TK values of more than 40 times the normal value were found in some patients. All patients with S-TK > 8.4 units had a disease that was or became progressive during the observation period. Within the patient group with indolent disease two groups that differed with regard to prognosis could be distinguished according to their initial S-TK values. In longitudinal studies of 18 patients with indolent disease, S-TK was found to exceed 8.4 units only on one occasion during an observation period of up to 68 months. In patients with indolent disease, a transition to progressive disease was parallelled by an increase in S-TK. Studies of S-TK levels in 18 patients receiving treatment showed that S-TK decreased during successful therapy. S-TK was also found to increase when the disease was reactivated. From these results it is concluded that S-TK could be used as a prognostic marker for the individual CLL patient. Furthermore, S-TK seems to be useful for longitudinal follow-up studies of disease status, both in indolent disease and in progressive disease during treatment." @default.
- W2094388623 created "2016-06-24" @default.
- W2094388623 creator A5013362434 @default.
- W2094388623 creator A5014696258 @default.
- W2094388623 creator A5040624896 @default.
- W2094388623 creator A5075849003 @default.
- W2094388623 date "1984-12-01" @default.
- W2094388623 modified "2023-09-23" @default.
- W2094388623 title "Serum deoxythymidine kinase gives prognostic information in chronic lymphocytic leukemia" @default.
- W2094388623 cites W154103547 @default.
- W2094388623 cites W1573862851 @default.
- W2094388623 cites W1946266003 @default.
- W2094388623 cites W1981535645 @default.
- W2094388623 cites W2005157472 @default.
- W2094388623 cites W2008212346 @default.
- W2094388623 cites W2011333667 @default.
- W2094388623 cites W2011862846 @default.
- W2094388623 cites W2013942619 @default.
- W2094388623 cites W2037668098 @default.
- W2094388623 cites W2038252730 @default.
- W2094388623 cites W2055235688 @default.
- W2094388623 cites W2079296807 @default.
- W2094388623 cites W2087006228 @default.
- W2094388623 cites W2088920936 @default.
- W2094388623 cites W2140547475 @default.
- W2094388623 cites W37889860 @default.
- W2094388623 doi "https://doi.org/10.1002/1097-0142(19841201)54:11<2450::aid-cncr2820541123>3.0.co;2-r" @default.
- W2094388623 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6498737" @default.
- W2094388623 hasPublicationYear "1984" @default.
- W2094388623 type Work @default.
- W2094388623 sameAs 2094388623 @default.
- W2094388623 citedByCount "105" @default.
- W2094388623 countsByYear W20943886232012 @default.
- W2094388623 countsByYear W20943886232013 @default.
- W2094388623 countsByYear W20943886232014 @default.
- W2094388623 countsByYear W20943886232015 @default.
- W2094388623 countsByYear W20943886232016 @default.
- W2094388623 countsByYear W20943886232018 @default.
- W2094388623 countsByYear W20943886232019 @default.
- W2094388623 countsByYear W20943886232020 @default.
- W2094388623 countsByYear W20943886232022 @default.
- W2094388623 crossrefType "journal-article" @default.
- W2094388623 hasAuthorship W2094388623A5013362434 @default.
- W2094388623 hasAuthorship W2094388623A5014696258 @default.
- W2094388623 hasAuthorship W2094388623A5040624896 @default.
- W2094388623 hasAuthorship W2094388623A5075849003 @default.
- W2094388623 hasConcept C126322002 @default.
- W2094388623 hasConcept C142724271 @default.
- W2094388623 hasConcept C146357865 @default.
- W2094388623 hasConcept C151730666 @default.
- W2094388623 hasConcept C2777938653 @default.
- W2094388623 hasConcept C2778461978 @default.
- W2094388623 hasConcept C2778822529 @default.
- W2094388623 hasConcept C2779134260 @default.
- W2094388623 hasConcept C71924100 @default.
- W2094388623 hasConcept C86803240 @default.
- W2094388623 hasConcept C90924648 @default.
- W2094388623 hasConceptScore W2094388623C126322002 @default.
- W2094388623 hasConceptScore W2094388623C142724271 @default.
- W2094388623 hasConceptScore W2094388623C146357865 @default.
- W2094388623 hasConceptScore W2094388623C151730666 @default.
- W2094388623 hasConceptScore W2094388623C2777938653 @default.
- W2094388623 hasConceptScore W2094388623C2778461978 @default.
- W2094388623 hasConceptScore W2094388623C2778822529 @default.
- W2094388623 hasConceptScore W2094388623C2779134260 @default.
- W2094388623 hasConceptScore W2094388623C71924100 @default.
- W2094388623 hasConceptScore W2094388623C86803240 @default.
- W2094388623 hasConceptScore W2094388623C90924648 @default.
- W2094388623 hasIssue "11" @default.
- W2094388623 hasLocation W20943886231 @default.
- W2094388623 hasLocation W20943886232 @default.
- W2094388623 hasOpenAccess W2094388623 @default.
- W2094388623 hasPrimaryLocation W20943886231 @default.
- W2094388623 hasRelatedWork W1986909167 @default.
- W2094388623 hasRelatedWork W2029120213 @default.
- W2094388623 hasRelatedWork W2332968797 @default.
- W2094388623 hasRelatedWork W2356105190 @default.
- W2094388623 hasRelatedWork W2418031697 @default.
- W2094388623 hasRelatedWork W2418633411 @default.
- W2094388623 hasRelatedWork W2469517166 @default.
- W2094388623 hasRelatedWork W4200389442 @default.
- W2094388623 hasRelatedWork W579273576 @default.
- W2094388623 hasRelatedWork W88401132 @default.
- W2094388623 hasVolume "54" @default.
- W2094388623 isParatext "false" @default.
- W2094388623 isRetracted "false" @default.
- W2094388623 magId "2094388623" @default.
- W2094388623 workType "article" @default.