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• W2094391391 abstract "An in vitro and in vivo study of some copper chelating anti-inflammatory agents for alleviation of inflammation associated with rheumatoid arthritis (RA) has been conducted. Two copper chelating agents, N1-(2-aminoethyl)-N2-(pyridin-2-ylmethyl)ethane-1,2-diamine ([555-N]) and N-(2-(2-aminoethylamino)ethyl)picolinamide ([H(555)-N]) have been synthesized as their hydrochloride salt; their protonation constants and formation constants with Cu(II), Zn(II) and Ca(II) determined by glass electrode potentiometry at 298 K and an ionic strength of 0.15 M. Cu(II) formed stable complexes at physiological pH while the in vivo competitors, Zn(II) and Ca(II) formed weak complexes with both chelating agents. Both [555-N] and [H(555)-N] showed better selectivity for Cu(II) than for Zn(II) and Ca(II). Electronic spectra for species formed at physiological pH suggest a square planar geometry. Speciation calculations using a blood plasma model predicted that these copper chelating agents are able to mobilize Cu(II) in vivo, while bio-distribution studies of their 64Cu(II)-labelled complexes at physiological pH showed tissue accumulation and retention indicating an encouraging biological half life." @default.
• W2094391391 created "2016-06-24" @default.
• W2094391391 creator A5045944093 @default.
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• W2094391391 date "2007-01-01" @default.
• W2094391391 modified "2023-09-27" @default.
• W2094391391 title "Copper chelating anti-inflammatory agents; N1-(2-aminoethyl)-N2-(pyridin-2-ylmethyl)-ethane-1,2-diamine and N-(2-(2-aminoethylamino)ethyl)picolinamide: An in vitro and in vivo study" @default.
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• W2094391391 doi "https://doi.org/10.1016/j.jinorgbio.2006.09.006" @default.
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