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• W2094391750 abstract "El objetivo de este trabajo es analizar la influencia de los factores de riesgo cardiovascular modificables en el ritmo circadiano del infarto agudo de miocardio. Análisis retrospectivo de 54.249 pacientes incluidos en la base de datos del proyecto ARIAM con diagnóstico de infarto agudo de miocardio. Se analizan las variables hora de inicio, edad, sexo, cardiopatía isquémica previa, estado en el momento del alta de la unidad coronaria, antecedentes familiares de cardiopatía isquémica, accidente cerebrovascular previo, hipertensión arterial, dislipemia, diabetes, tabaquismo y reinfarto. El análisis de ritmo se ha efectuado utilizando un test simple de igualdad de series basado en el análisis cosinor de múltiples sinusoides, eligiendo 3 armónicos (24,12 y 8 h) para su ajuste. La hora de inicio del infarto muestra ritmo circadiano (p < 0,01) con pico a las 10,07 y valle a las 4,46 h. Todos los subgrupos categorizados por la presencia de las variables analizadas presentaron ritmo circadiano, con una curva ajustada de aspecto sinusoidal. Los pacientes con diabetes, reinfarto y tabaquismo muestran una curva sinusoidal de aspecto bimodal. El infarto agudo de miocardio presenta ritmo circadiano. La diabetes, el tabaquismo y el reinfarto pueden modificar el ritmo habitual de aparición del infarto. The aim of this study was to analyze the influence of modifiable cardiovascular risk factors on the circadian rhythm of acute myocardial infarction. We analyzed a retrospective cohort of 54 249 patients from a multicenter study of acute myocardial infarction (the Spanish ARIAM study). The variables were time of onset of symptoms, age, sex, previous ischemic heart disease, coronary unit discharge status, previous stroke, familial antecedents of ischemic heart disease, hypertension, diabetes, dyslipidemia, smoking, and reinfarction. To verify the presence of circadian rhythm, we developed a simple test of equality of time series based on cosinor analysis of multiple sinusoid curves. Three sinusoids (24,12 and 8 hour periods) were used. The time of onset of pain showed a circadian rhythm (P<.01), with a peak at 10:07 am and a trough at 4:46 am. All subgroups categorized according to the presence of the variables analyzed here showed a circadian rhythm, with a sinusoid curve after adjustment. In patients with diabetes or reinfarction or who were smokers, the sinusoid curve was bimodal. Time of onset of symptoms in patients with acute myocardial infarction follows a circadian rhythm. Diabetes, smoking and reinfarction can modify the standard circadian rhythm of onset of myocardial infarction." @default.
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• W2094391750 date "2004-01-01" @default.
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• W2094391750 title "Factores de riesgo cardiovascular en el ritmo circadiano del infarto agudo de miocardio" @default.
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• W2094391750 doi "https://doi.org/10.1016/s0300-8932(04)77205-x" @default.
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