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• W2094392013 endingPage "12702" @default.
• W2094392013 startingPage "12692" @default.
• W2094392013 abstract "Heparan sulfate proteoglycans (HSPGs) are used by a number of viruses to facilitate entry into host cells. For the retrovirus human T-cell leukemia virus type 1 (HTLV-1), it has recently been reported that HSPGs are critical for efficient binding of soluble HTLV-1 SU and the entry of HTLV pseudotyped viruses into non-T cells. However, the primary in vivo targets of HTLV-1, CD4(+) T cells, have been reported to express low or undetectable levels of HSPGs. For this study, we reexamined the expression of HSPGs in CD4(+) T cells and examined their role in HTLV-1 attachment and entry. We observed that while quiescent primary CD4(+) T cells do not express detectable levels of HSPGs, HSPGs are expressed on primary CD4(+) T cells following immune activation. Enzymatic modification of HSPGs on the surfaces of either established CD4(+) T-cell lines or primary CD4(+) T cells dramatically reduced the binding of both soluble HTLV-1 SU and HTLV-1 virions. HSPGs also affected the efficiency of HTLV-1 entry, since blocking the interaction with HSPGs markedly reduced both the internalization of HTLV-1 virions and the titer of HTLV-1 pseudotyped viral infection in CD4(+) T cells. Thus, HSPGs play a critical role in the binding and entry of HTLV-1 into CD4(+) T cells." @default.
• W2094392013 created "2016-06-24" @default.
• W2094392013 creator A5020115662 @default.
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• W2094392013 creator A5070470409 @default.
• W2094392013 creator A5083465776 @default.
• W2094392013 date "2005-10-15" @default.
• W2094392013 modified "2023-09-26" @default.
• W2094392013 title "Heparan Sulfate Proteoglycans Mediate Attachment and Entry of Human T-Cell Leukemia Virus Type 1 Virions into CD4 ⁺ T Cells" @default.
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• W2094392013 doi "https://doi.org/10.1128/jvi.79.20.12692-12702.2005" @default.
• W2094392013 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1235841" @default.
• W2094392013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16188972" @default.
• W2094392013 hasPublicationYear "2005" @default.
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