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• W2094392044 endingPage "88" @default.
• W2094392044 startingPage "76" @default.
• W2094392044 abstract "Central amygdala nucleus (CeA)-periaqueductal gray (PAG) pathway is the component of descending antinociceptive circuitry. Nociceptin/orphanin FQ (N/OFQ) and nocistatin (NST) produce supraspinal pronociceptive and antinociceptive effects, respectively. We hypothesized that opposite effects of N/OFQ and NST on supraspinal pain modulation result from their opposing effects on the excitability of CeA-PAG projection neurons. This hypothesis was tested by investigating electrophysiological effects of N/OFQ and NST on medial CeA neurons that project to PAG (CeA(M)-PAG). N/OFQ hyperpolarized CeA(M)-PAG projection neurons by enhancing inwardly rectifying potassium conductance. In contrast, NST depolarized CeA(M)-PAG neurons by causing the opening of TRPC cation channels via G(alphaq/11)-PLC-PKC pathway. CeA(M)-PAG neurons hyperpolarized by N/OFQ express CRF or neurotensin mRNA. NST-responsive CeA(M)-PAG neurons contain CRF or substance P mRNA. Our study provides the evidence that the molecular and cellular basis for opposite effects of N/OFQ and NST on supraspinal pain regulation is their opposing effects on the excitability of peptidergic CeA(M)-PAG neurons." @default.
• W2094392044 created "2016-06-24" @default.
• W2094392044 creator A5009510828 @default.
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• W2094392044 creator A5036744490 @default.
• W2094392044 creator A5073166810 @default.
• W2094392044 creator A5084195908 @default.
• W2094392044 date "2009-01-01" @default.
• W2094392044 modified "2023-10-05" @default.
• W2094392044 title "Nocistatin and nociceptin exert opposite effects on the excitability of central amygdala nucleus-periaqueductal gray projection neurons" @default.
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• W2094392044 doi "https://doi.org/10.1016/j.mcn.2008.09.003" @default.
• W2094392044 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18930828" @default.
• W2094392044 hasPublicationYear "2009" @default.
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