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- W2094394903 abstract "Many promoters in eukaryotes have nucleosome-depleted regions (NDRs) containing transcription factor binding sites. However, the functional significance of NDRs is not well understood. Here, we examine NDR function in two cell cycle-regulated promoters, CLN2pr and HOpr, by varying nucleosomal coverage of the binding sites of their activator, Swi4/Swi6 cell-cycle box (SCB)-binding factor (SBF), and probing the corresponding transcriptional activity in individual cells with time-lapse microscopy. Nucleosome-embedded SCBs do not significantly alter peak expression levels. Instead, they induce bimodal, on/off activation in individual cell cycles, which displays short-term memory, or epigenetic inheritance, from the mother cycle. In striking contrast, the same SCBs localized in NDR lead to highly reliable activation, once in every cell cycle. We further demonstrate that the high variability in Cln2p expression induced by the nucleosomal SCBs reduces cell fitness. Therefore, we propose that the NDR function in limiting stochasticity in gene expression promotes the ubiquity and conservation of promoter NDR. PAPERCLIP:" @default.
- W2094394903 created "2016-06-24" @default.
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- W2094394903 date "2010-04-01" @default.
- W2094394903 modified "2023-10-18" @default.
- W2094394903 title "Nucleosome-Depleted Regions in Cell-Cycle-Regulated Promoters Ensure Reliable Gene Expression in Every Cell Cycle" @default.
- W2094394903 cites W1564217760 @default.
- W2094394903 cites W1593303365 @default.
- W2094394903 cites W1748844344 @default.
- W2094394903 cites W1807079294 @default.
- W2094394903 cites W1822988701 @default.
- W2094394903 cites W1846058178 @default.
- W2094394903 cites W1926397638 @default.
- W2094394903 cites W1968916935 @default.
- W2094394903 cites W1970970926 @default.
- W2094394903 cites W1972312016 @default.
- W2094394903 cites W1983386103 @default.
- W2094394903 cites W1984708728 @default.
- W2094394903 cites W1993009001 @default.
- W2094394903 cites W1994032485 @default.
- W2094394903 cites W2009253350 @default.
- W2094394903 cites W2011170131 @default.
- W2094394903 cites W2013947447 @default.
- W2094394903 cites W2014119967 @default.
- W2094394903 cites W2015038174 @default.
- W2094394903 cites W2016597274 @default.
- W2094394903 cites W2017550851 @default.
- W2094394903 cites W2019462270 @default.
- W2094394903 cites W2023630006 @default.
- W2094394903 cites W2029361184 @default.
- W2094394903 cites W2029521343 @default.
- W2094394903 cites W2030181771 @default.
- W2094394903 cites W2031467346 @default.
- W2094394903 cites W2034271226 @default.
- W2094394903 cites W2034961486 @default.
- W2094394903 cites W2035230904 @default.
- W2094394903 cites W2044681616 @default.
- W2094394903 cites W2044692345 @default.
- W2094394903 cites W2045159582 @default.
- W2094394903 cites W2045500168 @default.
- W2094394903 cites W2050298575 @default.
- W2094394903 cites W2056098889 @default.
- W2094394903 cites W2063679723 @default.
- W2094394903 cites W2067397907 @default.
- W2094394903 cites W2069233620 @default.
- W2094394903 cites W2072152932 @default.
- W2094394903 cites W2078300553 @default.
- W2094394903 cites W2078477504 @default.
- W2094394903 cites W2080498142 @default.
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- W2094394903 cites W2087177706 @default.
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- W2094394903 cites W2138908307 @default.
- W2094394903 cites W2140388293 @default.
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- W2094394903 doi "https://doi.org/10.1016/j.devcel.2010.02.007" @default.
- W2094394903 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2867244" @default.
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