FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094397320> ?p ?o ?g. }

• W2094397320 endingPage "810" @default.
• W2094397320 startingPage "806" @default.
• W2094397320 abstract "Syndecan-4 participates in focal adhesion by non-G protein-dependent activation of protein kinase C. Ligation of syndecan-4 with antithrombin elicits pertussis toxin-sensitive chemotaxis of leukocytes. As activation of protein kinase C stimulates release of sphingosine-1-phosphate, a chemoattracting G protein-coupled receptor agonist, we studied directional migration of leukocytes in response to phorbol myristate acetate (PMA), a direct activator of protein kinase C. Human peripheral blood neutrophils, monocytes, and lymphocytes were purified and tested for chemotactic migration in micropore filter assays in response to PMA. Dose-dependent stimulation of migration was seen only when leukocytes were exposed to concentration gradients of PMA; in the absence of such a gradient, inhibition of random migration was induced. Dimethylsphingosine inhibited PMA-induced leukocyte chemotaxis, indicating that activation of sphingosine kinase for enhanced production of sphingosine-1-phosphate mediates the chemotactic response to PMA. Pertussis toxin abrogated the chemotactic response to PMA, suggesting involvement of G protein-coupled sphingosine-1-phosphate receptor. Dimethylsphingosine also inhibited leukocyte chemotaxis toward antithrombin, indicating that similar mechanisms may be involved upon syndecan-4 ligation. Data show that protein kinase C-dependent activation of sphingosine kinase may play a central role in leukocyte chemotaxis toward non-G protein-coupled receptor agonists." @default.
• W2094397320 created "2016-06-24" @default.
• W2094397320 creator A5053282172 @default.
• W2094397320 creator A5056872170 @default.
• W2094397320 creator A5060957205 @default.
• W2094397320 creator A5085805107 @default.
• W2094397320 date "2002-10-01" @default.
• W2094397320 modified "2023-09-27" @default.
• W2094397320 title "Sphingosine kinase-dependent directional migration of leukocytes in response to phorbol ester" @default.
• W2094397320 cites W1421137972 @default.
• W2094397320 cites W1607819524 @default.
• W2094397320 cites W1978421075 @default.
• W2094397320 cites W1992046160 @default.
• W2094397320 cites W1993177711 @default.
• W2094397320 cites W1994248356 @default.
• W2094397320 cites W1996066976 @default.
• W2094397320 cites W1996192399 @default.
• W2094397320 cites W1996740801 @default.
• W2094397320 cites W2014993079 @default.
• W2094397320 cites W2020472510 @default.
• W2094397320 cites W2028959499 @default.
• W2094397320 cites W2045891730 @default.
• W2094397320 cites W2046913887 @default.
• W2094397320 cites W2057229979 @default.
• W2094397320 cites W2058240687 @default.
• W2094397320 cites W2062199188 @default.
• W2094397320 cites W2071068533 @default.
• W2094397320 cites W2116665768 @default.
• W2094397320 cites W2124642745 @default.
• W2094397320 cites W2141617119 @default.
• W2094397320 cites W2164522180 @default.
• W2094397320 doi "https://doi.org/10.1016/s0006-291x(02)02304-5" @default.
• W2094397320 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12359224" @default.
• W2094397320 hasPublicationYear "2002" @default.
• W2094397320 type Work @default.
• W2094397320 sameAs 2094397320 @default.
• W2094397320 citedByCount "18" @default.
• W2094397320 countsByYear W20943973202012 @default.
• W2094397320 countsByYear W20943973202013 @default.
• W2094397320 countsByYear W20943973202014 @default.
• W2094397320 countsByYear W20943973202016 @default.
• W2094397320 countsByYear W20943973202023 @default.
• W2094397320 crossrefType "journal-article" @default.
• W2094397320 hasAuthorship W2094397320A5053282172 @default.
• W2094397320 hasAuthorship W2094397320A5056872170 @default.
• W2094397320 hasAuthorship W2094397320A5060957205 @default.
• W2094397320 hasAuthorship W2094397320A5085805107 @default.
• W2094397320 hasConcept C153911025 @default.
• W2094397320 hasConcept C170493617 @default.
• W2094397320 hasConcept C184235292 @default.
• W2094397320 hasConcept C185592680 @default.
• W2094397320 hasConcept C195794163 @default.
• W2094397320 hasConcept C2776596873 @default.
• W2094397320 hasConcept C2777700496 @default.
• W2094397320 hasConcept C2778703144 @default.
• W2094397320 hasConcept C2779084600 @default.
• W2094397320 hasConcept C49773422 @default.
• W2094397320 hasConcept C54166955 @default.
• W2094397320 hasConcept C55493867 @default.
• W2094397320 hasConcept C62478195 @default.
• W2094397320 hasConcept C80631254 @default.
• W2094397320 hasConcept C86803240 @default.
• W2094397320 hasConcept C88045685 @default.
• W2094397320 hasConcept C95444343 @default.
• W2094397320 hasConcept C97029542 @default.
• W2094397320 hasConceptScore W2094397320C153911025 @default.
• W2094397320 hasConceptScore W2094397320C170493617 @default.
• W2094397320 hasConceptScore W2094397320C184235292 @default.
• W2094397320 hasConceptScore W2094397320C185592680 @default.
• W2094397320 hasConceptScore W2094397320C195794163 @default.
• W2094397320 hasConceptScore W2094397320C2776596873 @default.
• W2094397320 hasConceptScore W2094397320C2777700496 @default.
• W2094397320 hasConceptScore W2094397320C2778703144 @default.
• W2094397320 hasConceptScore W2094397320C2779084600 @default.
• W2094397320 hasConceptScore W2094397320C49773422 @default.
• W2094397320 hasConceptScore W2094397320C54166955 @default.
• W2094397320 hasConceptScore W2094397320C55493867 @default.
• W2094397320 hasConceptScore W2094397320C62478195 @default.
• W2094397320 hasConceptScore W2094397320C80631254 @default.
• W2094397320 hasConceptScore W2094397320C86803240 @default.
• W2094397320 hasConceptScore W2094397320C88045685 @default.
• W2094397320 hasConceptScore W2094397320C95444343 @default.
• W2094397320 hasConceptScore W2094397320C97029542 @default.
• W2094397320 hasIssue "4" @default.
• W2094397320 hasLocation W20943973201 @default.
• W2094397320 hasLocation W20943973202 @default.
• W2094397320 hasOpenAccess W2094397320 @default.
• W2094397320 hasPrimaryLocation W20943973201 @default.
• W2094397320 hasRelatedWork W1991048785 @default.
• W2094397320 hasRelatedWork W2030594678 @default.
• W2094397320 hasRelatedWork W2043913497 @default.
• W2094397320 hasRelatedWork W2083376185 @default.
• W2094397320 hasRelatedWork W2087068965 @default.
• W2094397320 hasRelatedWork W2094397320 @default.
• W2094397320 hasRelatedWork W2094754566 @default.
• W2094397320 hasRelatedWork W2140106917 @default.
• W2094397320 hasRelatedWork W2212472473 @default.
• W2094397320 hasRelatedWork W2368362977 @default.

• next