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• W2094400241 abstract "Abstract Background Experimental data imply that in decompensated heart failure ( HF ), the anti‐angiogenic factor endostatin is increased. This study aimed to investigate whether the angiogenesis inhibitor endostatin is related to the risk of all‐cause mortality in a prospective cohort study of chronic HF patients. Methods In this prospective observational cohort study, endostatin serum concentrations were determined in patients with chronic HF . Mortality data were recorded during a median follow‐up of 31 months. Results One fifty one patients were included. The overall mortality rate was 20%. Baseline endostatin concentrations > 245 ng/mL were associated with higher risk of all‐cause mortality [ HR 8·7 (95% CI 2·5–30·0); P = 0·001] in the multivariate analysis as compared to endostatin concentrations ≤ 245 ng/mL. When both endostatin and NT ‐pro BNP were above the calculated cut‐off of 245 ng/mL and 2386 pg/mL, respectively, the prognostic utility of both biomarkers increased [ HR 40·8 (95% CI 4·7–354·6); P = 0·001] compared with values lower than the cut‐offs. Conclusions Serum endostatin concentrations are independently associated with all‐cause mortality. Furthermore, combination of endostatin and NT ‐pro BNP discriminates patients at high risk." @default.
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• W2094400241 date "2013-11-28" @default.
• W2094400241 modified "2023-10-04" @default.
• W2094400241 title "Association of endostatin with mortality in patients with chronic heart failure" @default.
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• W2094400241 doi "https://doi.org/10.1111/eci.12197" @default.
• W2094400241 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24188329" @default.
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