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• W2094400979 abstract "<i>Background:</i> Alterations of the hypothalamic-pituitary-thyroid system at the hypophyseal level have been described in affective disorders. The NEO Five-Factor Inventory is a widely used instrument, which assesses neuroticism, a strong marker for vulnerability to depression. <i>Methods:</i> Endogenous serum concentrations of thyroid-stimulating hormone (TSH), free T3 and free T4 were measured and the NEO Five-Factor Inventory was performed in 121 healthy unrelated volunteers (51 male, 70 female; median age: 23 years, range from 17 to 71). <i>Results:</i> The TSH serum concentrations showed a median of 1.35 mU/l with a range from 0.1 to 4.0. The free T3 serum concentrations were 5.2 ± 0.7 pmol/l (mean ± SD), and the free T4 concentrations 16.5 ± 2.4 pmol/l (mean ± SD). The power of 0.4 of the TSH serum concentration and the logarithm of the depression-related factor neuroticism had a bivariate normal distribution and were negatively correlated (r = –0.337, p = 0.0002). <i>Conclusion:</i> Low TSH levels in healthy humans might be linked to an increased risk to develop depression." @default.
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• W2094400979 date "2007-01-01" @default.
• W2094400979 modified "2023-10-02" @default.
• W2094400979 title "Thyrotropin Serum Concentrations in Healthy Volunteers Are Associated with Depression-Related Personality Traits" @default.
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• W2094400979 doi "https://doi.org/10.1159/000112954" @default.
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