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- W2094401887 abstract "EGF is a low molecular weight polypeptide hormone which acts as a regulator of cell growth and differentiation. The A-431 cell line has been used frequently to examine receptor-mediated biochemical effects of EGF, since this cell line has an increased (20–50 fold) level of EGF receptors. We have utilized A-431 cells to examine the influence of EGF on formation of an intracellular second messenger, inositol 1,4,5-trisphosphate (Ins-1,4,5-P3), and other inositol phosphates. The results show that EGF induces rapid formation of Ins-1,4,5-P3 as well as Ins-1,3,4-P3 and Ins-1,3,4,5-P4. There is a concurrent decrease in the level of the lipid precursor for Ins-1,4,5-P3, phosphatidylinositol 4,5-bisphosphate (PIP2). Furthermore, we have examined five other cell lines that overexpress the EGF receptor and find that EGF treatment induces formation of inositol polyphosphates in those cell lines also." @default.
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- W2094401887 date "1987-02-01" @default.
- W2094401887 modified "2023-09-25" @default.
- W2094401887 title "Epidermal growth factor (EGF) stimulates inositol trisphosphate formation in cells which overexpress the EGF receptor" @default.
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- W2094401887 doi "https://doi.org/10.1016/0006-291x(87)91469-0" @default.
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