Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094403867> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2094403867 abstract "To characterize acidification by the distal nephron of the intact kidney independent of alterations in buffer availability, we subjected isolated rat kidneys perfused with glucose as the sole substrate to stepwise acidification of the perfusate. In response to progressive perfusate acidification with hydrochloric acid, a maximal pH gradient between urine and perfusate, which averaged 1.71 +/- 0.12, was achieved at a mean perfusate pH of 6.89 +/- 0.04. The maximum pH gradient was increased when sulfuric acid rather than hydrochloric acid was used to acidify the perfusate, and it was decreased by 0.67 when amiloride (10(-5) M) was added to the perfusate. Thus, hydrogen ion transport by the distal nephron of the intact rat kidney appears to be amenable to study, and it responds similarly to the hydrogen ion pump of anuran urinary epithelia. Kidneys from animals subjected to a variety of dietary regimens were studied in a response to stepwise perfusate acidification with hydrochloric acid. Ammonium excretion averaged 0.49 +/- .03 mumoles/min and did not differ significantly between any of the dietary groups. Chronic acidosis and the ingestion of either a low or high salt diet had no influence on the maximal pH gradient. Neither a low nor a high potassium diet affected the pH gradient, suggesting that the difference in urine pH between these two conditions in vivo is the result of differences in ammonia production. Ingestion of a high bicarbonate diet significantly decreased the pH gradient to 1.20 +/- 0.09. Thus, an adaptive change in distal nephron hydrogen ion transport occurs in the rat kidney in response to chronic ingestion of alkali." @default.
- W2094403867 created "2016-06-24" @default.
- W2094403867 creator A5007433269 @default.
- W2094403867 creator A5033250776 @default.
- W2094403867 date "1981-07-01" @default.
- W2094403867 modified "2023-09-27" @default.
- W2094403867 title "Characterization of acidification by the isolated perfused rat kidney: Evidence for adaptation by the distal nephron to a high bicarbonate diet" @default.
- W2094403867 cites W1852782425 @default.
- W2094403867 cites W1975055990 @default.
- W2094403867 cites W1978710590 @default.
- W2094403867 cites W1984635589 @default.
- W2094403867 cites W1985342306 @default.
- W2094403867 cites W2000410542 @default.
- W2094403867 cites W2051215995 @default.
- W2094403867 cites W2075036731 @default.
- W2094403867 cites W2104921182 @default.
- W2094403867 cites W2144039495 @default.
- W2094403867 cites W2180037647 @default.
- W2094403867 cites W2287268984 @default.
- W2094403867 cites W2314976695 @default.
- W2094403867 cites W2328638932 @default.
- W2094403867 cites W2337676142 @default.
- W2094403867 cites W2364682303 @default.
- W2094403867 cites W2396425135 @default.
- W2094403867 cites W2400821722 @default.
- W2094403867 cites W2416622053 @default.
- W2094403867 cites W2419180100 @default.
- W2094403867 cites W2431341975 @default.
- W2094403867 cites W3023044114 @default.
- W2094403867 doi "https://doi.org/10.1038/ki.1981.101" @default.
- W2094403867 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6272015" @default.
- W2094403867 hasPublicationYear "1981" @default.
- W2094403867 type Work @default.
- W2094403867 sameAs 2094403867 @default.
- W2094403867 citedByCount "9" @default.
- W2094403867 crossrefType "journal-article" @default.
- W2094403867 hasAuthorship W2094403867A5007433269 @default.
- W2094403867 hasAuthorship W2094403867A5033250776 @default.
- W2094403867 hasBestOaLocation W20944038671 @default.
- W2094403867 hasConcept C10146269 @default.
- W2094403867 hasConcept C126322002 @default.
- W2094403867 hasConcept C134018914 @default.
- W2094403867 hasConcept C158171629 @default.
- W2094403867 hasConcept C178790620 @default.
- W2094403867 hasConcept C185592680 @default.
- W2094403867 hasConcept C193230392 @default.
- W2094403867 hasConcept C2778553927 @default.
- W2094403867 hasConcept C2779608910 @default.
- W2094403867 hasConcept C2780091579 @default.
- W2094403867 hasConcept C2781112554 @default.
- W2094403867 hasConcept C2781231759 @default.
- W2094403867 hasConcept C537181965 @default.
- W2094403867 hasConcept C55493867 @default.
- W2094403867 hasConcept C71924100 @default.
- W2094403867 hasConcept C86803240 @default.
- W2094403867 hasConceptScore W2094403867C10146269 @default.
- W2094403867 hasConceptScore W2094403867C126322002 @default.
- W2094403867 hasConceptScore W2094403867C134018914 @default.
- W2094403867 hasConceptScore W2094403867C158171629 @default.
- W2094403867 hasConceptScore W2094403867C178790620 @default.
- W2094403867 hasConceptScore W2094403867C185592680 @default.
- W2094403867 hasConceptScore W2094403867C193230392 @default.
- W2094403867 hasConceptScore W2094403867C2778553927 @default.
- W2094403867 hasConceptScore W2094403867C2779608910 @default.
- W2094403867 hasConceptScore W2094403867C2780091579 @default.
- W2094403867 hasConceptScore W2094403867C2781112554 @default.
- W2094403867 hasConceptScore W2094403867C2781231759 @default.
- W2094403867 hasConceptScore W2094403867C537181965 @default.
- W2094403867 hasConceptScore W2094403867C55493867 @default.
- W2094403867 hasConceptScore W2094403867C71924100 @default.
- W2094403867 hasConceptScore W2094403867C86803240 @default.
- W2094403867 hasLocation W20944038671 @default.
- W2094403867 hasLocation W20944038672 @default.
- W2094403867 hasOpenAccess W2094403867 @default.
- W2094403867 hasPrimaryLocation W20944038671 @default.
- W2094403867 hasRelatedWork W1591312568 @default.
- W2094403867 hasRelatedWork W1993274286 @default.
- W2094403867 hasRelatedWork W2012393663 @default.
- W2094403867 hasRelatedWork W2039808805 @default.
- W2094403867 hasRelatedWork W2081516285 @default.
- W2094403867 hasRelatedWork W2094403867 @default.
- W2094403867 hasRelatedWork W2192837086 @default.
- W2094403867 hasRelatedWork W2305280864 @default.
- W2094403867 hasRelatedWork W2411914441 @default.
- W2094403867 hasRelatedWork W2496833708 @default.
- W2094403867 isParatext "false" @default.
- W2094403867 isRetracted "false" @default.
- W2094403867 magId "2094403867" @default.
- W2094403867 workType "article" @default.