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• W2094429710 abstract "Host cell factor-1 (HCF-1) is a metazoan transcriptional coregulator essential for cell-cycle progression and cell proliferation. Current models suggest a mechanism whereby HCF-1 functions as a direct coregulator of E2F proteins, facilitating the expression of genes necessary for cell proliferation. In this report, we show that HCF-1 recruitment to numerous E2F-bound promoters is mediated by the concerted action of zinc finger transcription factors THAP11 and ZNF143, rather than E2F proteins directly. THAP11, ZNF143, and HCF-1 form a mutually dependent complex on chromatin, which is independent of E2F occupancy. Disruption of the THAP11/ZNF143/HCF-1 complex results in altered expression of cell-cycle control genes and leads to reduced cell proliferation, cell-cycle progression, and cell viability. These data establish a model in which a THAP11/ZNF143/HCF-1 complex is a critical component of the transcriptional regulatory network governing cell proliferation." @default.
• W2094429710 created "2016-06-24" @default.
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• W2094429710 date "2014-11-01" @default.
• W2094429710 modified "2023-10-18" @default.
• W2094429710 title "Host Cell Factor-1 Recruitment to E2F-Bound and Cell-Cycle-Control Genes Is Mediated by THAP11 and ZNF143" @default.
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• W2094429710 doi "https://doi.org/10.1016/j.celrep.2014.09.051" @default.
• W2094429710 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4250832" @default.
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