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• W2094465805 abstract "Abstract Background Microvascular injury and epithelial barrier dysfunction are rate-limiting aspects in radiation enteropathy. This study examined the role of p38 mitogen-activated protein kinase (p38 MAPK) signalling in radiation-induced colitis in an experimental model. Methods The p38 MAPK inhibitor SB239063 was administered to mice immediately before exposure to 20 Gy radiation. Leucocyte– and platelet–endothelium interactions in the colonic microcirculation were assessed by intravital microscopy. Levels of myeloperoxidase (MPO) and CXC chemokines (macrophage inflammatory protein (MIP) 2 and cytokine-induced neutrophil chemoattractant (KC)), and albumin leakage were quantified 16 h after irradiation. Results Irradiation induced an increase in leucocyte and platelet recruitment, MPO activity, CXC chemokine levels and intestinal leakage. Inhibition of p38 MAPK by SB239063 decreased radiation-induced leucocyte and platelet recruitment (leucocyte rolling and adhesion by 70 and 90 per cent, both P &lt; 0·001; that of platelets by 70 and 74 per cent, both P &lt; 0·001). It also reduced radiation-provoked increases in colonic MPO activity by 88 per cent (P &lt; 0·001), formation of MIP-2 and KC by 72 and 74 per cent respectively (P = 0·003 and P &lt; 0·001), and intestinal leakage by 81 per cent (P &lt; 0·001). Conclusion p38 MAPK is an important signalling pathway in radiation-induced colitis." @default.
• W2094465805 created "2016-06-24" @default.
• W2094465805 creator A5055946443 @default.
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• W2094465805 date "2009-12-23" @default.
• W2094465805 modified "2023-10-16" @default.
• W2094465805 title "p38 Mitogen-activated protein kinase signalling regulates vascular inflammation and epithelial barrier dysfunction in an experimental model of radiation-induced colitis" @default.
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• W2094465805 doi "https://doi.org/10.1002/bjs.6811" @default.
• W2094465805 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20034051" @default.
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