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• W2094476260 abstract "We constructed expression libraries for Lac repressor mutants with amino acid exchanges in positions 1, 2, 5 and 9 of the recognition helix. We then analysed the interactions of residues 5 and 9 with operator variants bearing single or multiple symmetric base-pair exchanges in positions 3, 4 and 5 of the ideal fully symmetric lac operator. We isolated 37 independent Lac repressor mutants with five different amino acids in position 5 of the recognition helix that exhibit a strong preference for particular residues in position 2 and, to a lesser extent, in position 1 of the recognition helix. Our results suggest that residue 5 of the recognition helix (serine 21) contributes to the specific recognition of base-pair 4 of the lac operator. They further suggest that residue 9 of the recognition helix (asparagine 25) interacts non-specifically with a phosphate of the DNA backbone, possibly between base-pairs 2 and 3." @default.
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• W2094476260 date "1991-03-01" @default.
• W2094476260 modified "2023-10-18" @default.
• W2094476260 title "The roles of residues 5 and 9 of the recognition helix of Lac repressor in lac operator binding" @default.
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• W2094476260 doi "https://doi.org/10.1016/0022-2836(91)90714-h" @default.
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