FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094479423> ?p ?o ?g. }

• W2094479423 endingPage "440" @default.
• W2094479423 startingPage "431" @default.
• W2094479423 abstract "Alpha-tocopherol but not 2-carboxy-2,5,7,8-tetramethyl-6-chromanol (trolox or CTMC) and 2,2,5,7,8 pentamethyl-6-hydroxy chromane (PMC), derivatives of alpha-tocopherol, inhibited the superoxide (O2-.) generation of rat peritoneal neutrophils (RPMN) induced by phorbol 12-myrisate 13-acetate (PMA). ID50 for neutrophils obtained from the peritoneal cavity of rat and guinea pig was about 1microM. This concentration, however, was much lower than that for the inhibition of PMA-activated phospholipid-dependent protein kinase (PKC) (ID50 = 30 microM). The alpha-tocopherol sensitive O2-. generation was also observed in neutrophils induced by dioctanoylglycerol (diC8) and calcium ionophore A23187 but not by formylmethionyl-leucyl-phenylalanine (FMLP), opsonized zymosan (OZ) and sodium dodecyl sulfate (SDS). The pattern of inhibition by alpha-tocopherol was quite similar to that of staurosporine, a specific inhibitor of PKC. The alpha-tocopherol content of RPMN was 12 ng/10(6) cells and a linear increase to 200 ng/10(6) cells by addition of alpha-tocopherol to the cell suspension corresponded with an increased inhibition of O2-. generation. These results indicate that both the chemical structure and the content of alpha-tocopherol might be important factors in O2-. generation by neutrophils." @default.
• W2094479423 created "2016-06-24" @default.
• W2094479423 creator A5008991798 @default.
• W2094479423 creator A5022633859 @default.
• W2094479423 creator A5024440086 @default.
• W2094479423 creator A5027489861 @default.
• W2094479423 creator A5051332792 @default.
• W2094479423 creator A5068374445 @default.
• W2094479423 creator A5075357308 @default.
• W2094479423 creator A5089190393 @default.
• W2094479423 date "1995-01-01" @default.
• W2094479423 modified "2023-09-26" @default.
• W2094479423 title "Inhibition of Stimulus-Specific Neutrophil Superoxide Generation by Alpha-Tocopherol" @default.
• W2094479423 cites W1480655900 @default.
• W2094479423 cites W1484415245 @default.
• W2094479423 cites W1486414742 @default.
• W2094479423 cites W1508727703 @default.
• W2094479423 cites W1515168754 @default.
• W2094479423 cites W1583483795 @default.
• W2094479423 cites W1589866689 @default.
• W2094479423 cites W1620795530 @default.
• W2094479423 cites W1656644300 @default.
• W2094479423 cites W1963820921 @default.
• W2094479423 cites W1964691080 @default.
• W2094479423 cites W1974559970 @default.
• W2094479423 cites W1982857351 @default.
• W2094479423 cites W1995234500 @default.
• W2094479423 cites W2008836533 @default.
• W2094479423 cites W2011302715 @default.
• W2094479423 cites W2018583502 @default.
• W2094479423 cites W2027512912 @default.
• W2094479423 cites W2040217192 @default.
• W2094479423 cites W2050768620 @default.
• W2094479423 cites W2063547171 @default.
• W2094479423 cites W2072256028 @default.
• W2094479423 cites W2090736145 @default.
• W2094479423 cites W2147244719 @default.
• W2094479423 doi "https://doi.org/10.3109/10715769509147551" @default.
• W2094479423 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7633571" @default.
• W2094479423 hasPublicationYear "1995" @default.
• W2094479423 type Work @default.
• W2094479423 sameAs 2094479423 @default.
• W2094479423 citedByCount "52" @default.
• W2094479423 countsByYear W20944794232012 @default.
• W2094479423 countsByYear W20944794232016 @default.
• W2094479423 countsByYear W20944794232018 @default.
• W2094479423 crossrefType "journal-article" @default.
• W2094479423 hasAuthorship W2094479423A5008991798 @default.
• W2094479423 hasAuthorship W2094479423A5022633859 @default.
• W2094479423 hasAuthorship W2094479423A5024440086 @default.
• W2094479423 hasAuthorship W2094479423A5027489861 @default.
• W2094479423 hasAuthorship W2094479423A5051332792 @default.
• W2094479423 hasAuthorship W2094479423A5068374445 @default.
• W2094479423 hasAuthorship W2094479423A5075357308 @default.
• W2094479423 hasAuthorship W2094479423A5089190393 @default.
• W2094479423 hasConcept C153911025 @default.
• W2094479423 hasConcept C181199279 @default.
• W2094479423 hasConcept C184235292 @default.
• W2094479423 hasConcept C185592680 @default.
• W2094479423 hasConcept C195794163 @default.
• W2094479423 hasConcept C202751555 @default.
• W2094479423 hasConcept C2775838275 @default.
• W2094479423 hasConcept C2776231299 @default.
• W2094479423 hasConcept C2777551382 @default.
• W2094479423 hasConcept C2778004101 @default.
• W2094479423 hasConcept C2778870864 @default.
• W2094479423 hasConcept C2779084600 @default.
• W2094479423 hasConcept C2779924751 @default.
• W2094479423 hasConcept C2780795997 @default.
• W2094479423 hasConcept C2781401929 @default.
• W2094479423 hasConcept C2781449162 @default.
• W2094479423 hasConcept C2909761558 @default.
• W2094479423 hasConcept C55493867 @default.
• W2094479423 hasConcept C86803240 @default.
• W2094479423 hasConcept C99971728 @default.
• W2094479423 hasConceptScore W2094479423C153911025 @default.
• W2094479423 hasConceptScore W2094479423C181199279 @default.
• W2094479423 hasConceptScore W2094479423C184235292 @default.
• W2094479423 hasConceptScore W2094479423C185592680 @default.
• W2094479423 hasConceptScore W2094479423C195794163 @default.
• W2094479423 hasConceptScore W2094479423C202751555 @default.
• W2094479423 hasConceptScore W2094479423C2775838275 @default.
• W2094479423 hasConceptScore W2094479423C2776231299 @default.
• W2094479423 hasConceptScore W2094479423C2777551382 @default.
• W2094479423 hasConceptScore W2094479423C2778004101 @default.
• W2094479423 hasConceptScore W2094479423C2778870864 @default.
• W2094479423 hasConceptScore W2094479423C2779084600 @default.
• W2094479423 hasConceptScore W2094479423C2779924751 @default.
• W2094479423 hasConceptScore W2094479423C2780795997 @default.
• W2094479423 hasConceptScore W2094479423C2781401929 @default.
• W2094479423 hasConceptScore W2094479423C2781449162 @default.
• W2094479423 hasConceptScore W2094479423C2909761558 @default.
• W2094479423 hasConceptScore W2094479423C55493867 @default.
• W2094479423 hasConceptScore W2094479423C86803240 @default.
• W2094479423 hasConceptScore W2094479423C99971728 @default.
• W2094479423 hasIssue "5" @default.
• W2094479423 hasLocation W20944794231 @default.
• W2094479423 hasLocation W20944794232 @default.

• next