FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094479838> ?p ?o ?g. }

• W2094479838 endingPage "940" @default.
• W2094479838 startingPage "929" @default.
• W2094479838 abstract "We utilize structurally targeted peptides to identify a tC fusion switch inherent to the coil domains of the neuronal t-SNARE that pairs with the cognate v-SNARE. The tC fusion switch is located in the membrane-proximal portion of the t-SNARE and controls the rate at which the helical bundle that forms the SNAREpin can zip up to drive bilayer fusion. When the fusion switch is off (the intrinsic state of the t-SNARE), zippering of the helices from their membrane-distal ends is impeded and fusion is slow. When the tC fusion switch is on, fusion is much faster. The tC fusion switch can be thrown by a peptide that corresponds to the membrane-proximal half of the cognate v-SNARE, and binds reversibly to the cognate region of the t-SNARE. This structures the coil in the membrane-proximal domain of the t-SNARE and accelerates fusion, implying that the intrinsically unstable coil in that region is a natural impediment to the completion of zippering, and thus, fusion. Proteins that stabilize or destabilize one or the other state of the tC fusion switch would exert fine temporal control over the rate of fusion after SNAREs have already partly zippered up." @default.
• W2094479838 created "2016-06-24" @default.
• W2094479838 creator A5011277647 @default.
• W2094479838 creator A5016149761 @default.
• W2094479838 creator A5019657763 @default.
• W2094479838 creator A5033967319 @default.
• W2094479838 creator A5039150236 @default.
• W2094479838 creator A5049515262 @default.
• W2094479838 creator A5072736231 @default.
• W2094479838 creator A5085275965 @default.
• W2094479838 creator A5088789618 @default.
• W2094479838 date "2002-09-02" @default.
• W2094479838 modified "2023-10-01" @default.
• W2094479838 title "Regulation of membrane fusion by the membrane-proximal coil of the t-SNARE during zippering of SNAREpins" @default.
• W2094479838 cites W1533509738 @default.
• W2094479838 cites W1540559701 @default.
• W2094479838 cites W1543112938 @default.
• W2094479838 cites W1544228065 @default.
• W2094479838 cites W1555714096 @default.
• W2094479838 cites W1570678799 @default.
• W2094479838 cites W1574626580 @default.
• W2094479838 cites W1600427108 @default.
• W2094479838 cites W1607355583 @default.
• W2094479838 cites W162350361 @default.
• W2094479838 cites W170382783 @default.
• W2094479838 cites W1822252127 @default.
• W2094479838 cites W1905416680 @default.
• W2094479838 cites W1966364658 @default.
• W2094479838 cites W1976479871 @default.
• W2094479838 cites W1980886488 @default.
• W2094479838 cites W1990630751 @default.
• W2094479838 cites W1990895654 @default.
• W2094479838 cites W1996598000 @default.
• W2094479838 cites W1999213641 @default.
• W2094479838 cites W2002669633 @default.
• W2094479838 cites W2013561554 @default.
• W2094479838 cites W2014222535 @default.
• W2094479838 cites W2019319677 @default.
• W2094479838 cites W2020222865 @default.
• W2094479838 cites W2022977995 @default.
• W2094479838 cites W2027738518 @default.
• W2094479838 cites W2027775552 @default.
• W2094479838 cites W2036656105 @default.
• W2094479838 cites W2045144602 @default.
• W2094479838 cites W2051103934 @default.
• W2094479838 cites W2052937897 @default.
• W2094479838 cites W2056182641 @default.
• W2094479838 cites W2063487710 @default.
• W2094479838 cites W2065220292 @default.
• W2094479838 cites W2067354100 @default.
• W2094479838 cites W2085370553 @default.
• W2094479838 cites W2085680244 @default.
• W2094479838 cites W2086696756 @default.
• W2094479838 cites W2101532102 @default.
• W2094479838 cites W2118639186 @default.
• W2094479838 cites W2123355036 @default.
• W2094479838 cites W2136687453 @default.
• W2094479838 cites W2139420483 @default.
• W2094479838 doi "https://doi.org/10.1083/jcb.200112081" @default.
• W2094479838 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2173141" @default.
• W2094479838 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12213837" @default.
• W2094479838 hasPublicationYear "2002" @default.
• W2094479838 type Work @default.
• W2094479838 sameAs 2094479838 @default.
• W2094479838 citedByCount "200" @default.
• W2094479838 countsByYear W20944798382012 @default.
• W2094479838 countsByYear W20944798382013 @default.
• W2094479838 countsByYear W20944798382014 @default.
• W2094479838 countsByYear W20944798382015 @default.
• W2094479838 countsByYear W20944798382016 @default.
• W2094479838 countsByYear W20944798382017 @default.
• W2094479838 countsByYear W20944798382018 @default.
• W2094479838 countsByYear W20944798382019 @default.
• W2094479838 countsByYear W20944798382020 @default.
• W2094479838 countsByYear W20944798382021 @default.
• W2094479838 countsByYear W20944798382022 @default.
• W2094479838 countsByYear W20944798382023 @default.
• W2094479838 crossrefType "journal-article" @default.
• W2094479838 hasAuthorship W2094479838A5011277647 @default.
• W2094479838 hasAuthorship W2094479838A5016149761 @default.
• W2094479838 hasAuthorship W2094479838A5019657763 @default.
• W2094479838 hasAuthorship W2094479838A5033967319 @default.
• W2094479838 hasAuthorship W2094479838A5039150236 @default.
• W2094479838 hasAuthorship W2094479838A5049515262 @default.
• W2094479838 hasAuthorship W2094479838A5072736231 @default.
• W2094479838 hasAuthorship W2094479838A5085275965 @default.
• W2094479838 hasAuthorship W2094479838A5088789618 @default.
• W2094479838 hasBestOaLocation W20944798381 @default.
• W2094479838 hasConcept C103038307 @default.
• W2094479838 hasConcept C104317684 @default.
• W2094479838 hasConcept C105782903 @default.
• W2094479838 hasConcept C11413529 @default.
• W2094479838 hasConcept C123894998 @default.
• W2094479838 hasConcept C12554922 @default.
• W2094479838 hasConcept C138885662 @default.
• W2094479838 hasConcept C158525013 @default.
• W2094479838 hasConcept C2908790754 @default.
• W2094479838 hasConcept C40767141 @default.

• next