FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094480961> ?p ?o ?g. }

• W2094480961 endingPage "5041" @default.
• W2094480961 startingPage "5030" @default.
• W2094480961 abstract "C-type natriuretic peptide (CNP) has recently been identified as a key anabolic regulator of endochondral bone growth, but the cellular and molecular mechanisms involved are incompletely understood. Although CNP has been shown to stimulate proliferation and hypertrophic differentiation of growth plate chondrocytes, it is unknown whether CNP affects the earliest stages of endochondral bone development, condensation of mesenchymal precursor cells, and chondrogenesis. Here we demonstrate that CNP increases the number of chondrogenic condensations of mouse embryonic limb bud cells in micromass culture. This is accompanied by increased expression of the cell adhesion molecule N-cadherin. In addition, CNP stimulates glycosaminoglycan synthesis as indicated by increased Alcian blue staining. However, expression of the chondrogenic transcription factors Sox9, -5, and -6 or of the main extracellular matrix genes encoding collagen II and aggrecan is not affected by CNP. Instead, we show that CNP increases expression of enzymes involved in chondroitin sulfate synthesis, a required step in the production of cartilage glycosaminoglycans. In summary, we demonstrate a novel role of CNP in promoting chondrogenesis by stimulating expression of molecules involved in cell adhesion molecules and glycosaminoglycan synthesis." @default.
• W2094480961 created "2016-06-24" @default.
• W2094480961 creator A5075865392 @default.
• W2094480961 creator A5080549180 @default.
• W2094480961 creator A5087035379 @default.
• W2094480961 date "2007-10-01" @default.
• W2094480961 modified "2023-10-16" @default.
• W2094480961 title "C-Type Natriuretic Peptide Regulates Cellular Condensation and Glycosaminoglycan Synthesis during Chondrogenesis" @default.
• W2094480961 cites W1496206652 @default.
• W2094480961 cites W1526474070 @default.
• W2094480961 cites W1574722884 @default.
• W2094480961 cites W1586489547 @default.
• W2094480961 cites W1598470014 @default.
• W2094480961 cites W1977700828 @default.
• W2094480961 cites W1983529894 @default.
• W2094480961 cites W1985785796 @default.
• W2094480961 cites W1991072099 @default.
• W2094480961 cites W1997299799 @default.
• W2094480961 cites W2007762330 @default.
• W2094480961 cites W2016800171 @default.
• W2094480961 cites W2023340761 @default.
• W2094480961 cites W2026201824 @default.
• W2094480961 cites W2032244667 @default.
• W2094480961 cites W2032380793 @default.
• W2094480961 cites W2033940805 @default.
• W2094480961 cites W2034140040 @default.
• W2094480961 cites W2037510780 @default.
• W2094480961 cites W2039434926 @default.
• W2094480961 cites W2040325305 @default.
• W2094480961 cites W2042143409 @default.
• W2094480961 cites W2042932723 @default.
• W2094480961 cites W2043568167 @default.
• W2094480961 cites W2045458074 @default.
• W2094480961 cites W2047459846 @default.
• W2094480961 cites W2049015255 @default.
• W2094480961 cites W2056508838 @default.
• W2094480961 cites W2058877705 @default.
• W2094480961 cites W2065584680 @default.
• W2094480961 cites W2085927993 @default.
• W2094480961 cites W2086679033 @default.
• W2094480961 cites W2087178104 @default.
• W2094480961 cites W2088120545 @default.
• W2094480961 cites W2088633520 @default.
• W2094480961 cites W2096385528 @default.
• W2094480961 cites W2098150638 @default.
• W2094480961 cites W2102047286 @default.
• W2094480961 cites W2112893967 @default.
• W2094480961 cites W2119455028 @default.
• W2094480961 cites W2122883560 @default.
• W2094480961 cites W2128725121 @default.
• W2094480961 cites W2132837491 @default.
• W2094480961 cites W2133526415 @default.
• W2094480961 cites W2133789497 @default.
• W2094480961 cites W2138094668 @default.
• W2094480961 cites W2142335737 @default.
• W2094480961 cites W2154967508 @default.
• W2094480961 cites W2158411945 @default.
• W2094480961 cites W2171707147 @default.
• W2094480961 cites W2395742742 @default.
• W2094480961 doi "https://doi.org/10.1210/en.2007-0695" @default.
• W2094480961 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17640987" @default.
• W2094480961 hasPublicationYear "2007" @default.
• W2094480961 type Work @default.
• W2094480961 sameAs 2094480961 @default.
• W2094480961 citedByCount "40" @default.
• W2094480961 countsByYear W20944809612012 @default.
• W2094480961 countsByYear W20944809612013 @default.
• W2094480961 countsByYear W20944809612014 @default.
• W2094480961 countsByYear W20944809612015 @default.
• W2094480961 countsByYear W20944809612016 @default.
• W2094480961 countsByYear W20944809612017 @default.
• W2094480961 countsByYear W20944809612019 @default.
• W2094480961 countsByYear W20944809612021 @default.
• W2094480961 countsByYear W20944809612022 @default.
• W2094480961 countsByYear W20944809612023 @default.
• W2094480961 crossrefType "journal-article" @default.
• W2094480961 hasAuthorship W2094480961A5075865392 @default.
• W2094480961 hasAuthorship W2094480961A5080549180 @default.
• W2094480961 hasAuthorship W2094480961A5087035379 @default.
• W2094480961 hasBestOaLocation W20944809611 @default.
• W2094480961 hasConcept C105702510 @default.
• W2094480961 hasConcept C126322002 @default.
• W2094480961 hasConcept C134018914 @default.
• W2094480961 hasConcept C142724271 @default.
• W2094480961 hasConcept C153074725 @default.
• W2094480961 hasConcept C17938293 @default.
• W2094480961 hasConcept C185592680 @default.
• W2094480961 hasConcept C189165786 @default.
• W2094480961 hasConcept C196843134 @default.
• W2094480961 hasConcept C197534660 @default.
• W2094480961 hasConcept C198826908 @default.
• W2094480961 hasConcept C204787440 @default.
• W2094480961 hasConcept C25770073 @default.
• W2094480961 hasConcept C2776164576 @default.
• W2094480961 hasConcept C2779553658 @default.
• W2094480961 hasConcept C2780550940 @default.
• W2094480961 hasConcept C2781013607 @default.
• W2094480961 hasConcept C3020332539 @default.

• next