Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094487061> ?p ?o ?g. }
- W2094487061 endingPage "3051" @default.
- W2094487061 startingPage "3047" @default.
- W2094487061 abstract "Prior to the release of flavivirus particles from infected cells, the viral surface protein prM is cleaved to M by the cellular enzyme furin. For dengue virus (DENV), this maturation process appears to be very inefficient since a high proportion of progeny virions contain uncleaved prM. Furthermore, it has been reported that prM-containing DENV particles are infectious. These observations contradict the general assumption that prM processing is required to render virus particles infectious. Therefore, in this study, we reinvestigated the infectious properties of immature DENV virions. DENV particles were produced in furin-deficient LoVo cells. We observed that DENV-infected LoVo cells secrete high numbers of prM-containing particles. Subsequent analysis of the infectious titre revealed that immature particles lack the ability to infect cells, the infectious unit to particle ratio being 10 000-fold reduced compared with that of wild-type virus. Our results indicate that cleavage of prM to M is required for DENV infectivity." @default.
- W2094487061 created "2016-06-24" @default.
- W2094487061 creator A5046661576 @default.
- W2094487061 creator A5047921978 @default.
- W2094487061 creator A5060662043 @default.
- W2094487061 creator A5063577800 @default.
- W2094487061 date "2008-12-01" @default.
- W2094487061 modified "2023-09-26" @default.
- W2094487061 title "Functional importance of dengue virus maturation: infectious properties of immature virions" @default.
- W2094487061 cites W1505989132 @default.
- W2094487061 cites W1522956214 @default.
- W2094487061 cites W1542778496 @default.
- W2094487061 cites W1580601990 @default.
- W2094487061 cites W1588863545 @default.
- W2094487061 cites W1599389506 @default.
- W2094487061 cites W1966277979 @default.
- W2094487061 cites W1991576220 @default.
- W2094487061 cites W1998293016 @default.
- W2094487061 cites W2002771588 @default.
- W2094487061 cites W2019660826 @default.
- W2094487061 cites W2023274598 @default.
- W2094487061 cites W2034125106 @default.
- W2094487061 cites W2062183101 @default.
- W2094487061 cites W2079991074 @default.
- W2094487061 cites W2091058727 @default.
- W2094487061 cites W2098390821 @default.
- W2094487061 cites W2098687402 @default.
- W2094487061 cites W2102264941 @default.
- W2094487061 cites W2107026123 @default.
- W2094487061 cites W2107777154 @default.
- W2094487061 cites W2124774944 @default.
- W2094487061 cites W2133431128 @default.
- W2094487061 cites W2141349592 @default.
- W2094487061 cites W2146321324 @default.
- W2094487061 cites W2152542121 @default.
- W2094487061 cites W2158483704 @default.
- W2094487061 cites W2162607832 @default.
- W2094487061 cites W2417092441 @default.
- W2094487061 doi "https://doi.org/10.1099/vir.0.2008/002535-0" @default.
- W2094487061 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19008392" @default.
- W2094487061 hasPublicationYear "2008" @default.
- W2094487061 type Work @default.
- W2094487061 sameAs 2094487061 @default.
- W2094487061 citedByCount "145" @default.
- W2094487061 countsByYear W20944870612012 @default.
- W2094487061 countsByYear W20944870612013 @default.
- W2094487061 countsByYear W20944870612014 @default.
- W2094487061 countsByYear W20944870612015 @default.
- W2094487061 countsByYear W20944870612016 @default.
- W2094487061 countsByYear W20944870612017 @default.
- W2094487061 countsByYear W20944870612018 @default.
- W2094487061 countsByYear W20944870612019 @default.
- W2094487061 countsByYear W20944870612020 @default.
- W2094487061 countsByYear W20944870612021 @default.
- W2094487061 countsByYear W20944870612022 @default.
- W2094487061 countsByYear W20944870612023 @default.
- W2094487061 crossrefType "journal-article" @default.
- W2094487061 hasAuthorship W2094487061A5046661576 @default.
- W2094487061 hasAuthorship W2094487061A5047921978 @default.
- W2094487061 hasAuthorship W2094487061A5060662043 @default.
- W2094487061 hasAuthorship W2094487061A5063577800 @default.
- W2094487061 hasBestOaLocation W20944870611 @default.
- W2094487061 hasConcept C106358424 @default.
- W2094487061 hasConcept C159047783 @default.
- W2094487061 hasConcept C181199279 @default.
- W2094487061 hasConcept C202878990 @default.
- W2094487061 hasConcept C2522874641 @default.
- W2094487061 hasConcept C2777265534 @default.
- W2094487061 hasConcept C2779635636 @default.
- W2094487061 hasConcept C2780568436 @default.
- W2094487061 hasConcept C32611913 @default.
- W2094487061 hasConcept C533803919 @default.
- W2094487061 hasConcept C55493867 @default.
- W2094487061 hasConcept C86803240 @default.
- W2094487061 hasConcept C89138240 @default.
- W2094487061 hasConceptScore W2094487061C106358424 @default.
- W2094487061 hasConceptScore W2094487061C159047783 @default.
- W2094487061 hasConceptScore W2094487061C181199279 @default.
- W2094487061 hasConceptScore W2094487061C202878990 @default.
- W2094487061 hasConceptScore W2094487061C2522874641 @default.
- W2094487061 hasConceptScore W2094487061C2777265534 @default.
- W2094487061 hasConceptScore W2094487061C2779635636 @default.
- W2094487061 hasConceptScore W2094487061C2780568436 @default.
- W2094487061 hasConceptScore W2094487061C32611913 @default.
- W2094487061 hasConceptScore W2094487061C533803919 @default.
- W2094487061 hasConceptScore W2094487061C55493867 @default.
- W2094487061 hasConceptScore W2094487061C86803240 @default.
- W2094487061 hasConceptScore W2094487061C89138240 @default.
- W2094487061 hasIssue "12" @default.
- W2094487061 hasLocation W20944870611 @default.
- W2094487061 hasLocation W20944870612 @default.
- W2094487061 hasOpenAccess W2094487061 @default.
- W2094487061 hasPrimaryLocation W20944870611 @default.
- W2094487061 hasRelatedWork W1893895415 @default.
- W2094487061 hasRelatedWork W2023274598 @default.
- W2094487061 hasRelatedWork W2049763445 @default.
- W2094487061 hasRelatedWork W2076100628 @default.
- W2094487061 hasRelatedWork W2094487061 @default.