FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094492063> ?p ?o ?g. }

• W2094492063 endingPage "101" @default.
• W2094492063 startingPage "95" @default.
• W2094492063 abstract "Heparin cofactor II is postulated to be an extravascular thrombin inhibitor that is physiologically stimulated by dermatan sulfate. However, the role of heparin cofactor II has not yet been clearly demonstrated in vivo. In this study, we estimated the antithrombotic effect of heparin cofactor II administered exogenously in a rat model of thrombosis. Thrombus was induced in the rat femoral artery by endothelial damage due to the photochemical reaction between systemically injected rose bengal and transillumination with green light. Pretreatment with heparin cofactor II significantly prolonged the time required to occlude the femoral artery (occlusion time) in a dose-dependent manner. At an effective dose in this thrombosis model, heparin cofactor II did not prolong the activated partial thromboplastin time and the prothrombin time in normal rats. Argatroban, a selective synthetic thrombin inhibitor, significantly prolonged the occlusion time. However, argatroban also prolonged the activated partial thromboplastin time and prothrombin time at an effective dose. These results suggest that the administration of heparin cofactor II in vivo effectively inhibited thrombus formation on the vessel walls whose endothelium is damaged without a prolongation of the coagulation time while heparin cofactor II may also inhibit the thrombin activity in the subendothelial tissue in vivo." @default.
• W2094492063 created "2016-06-24" @default.
• W2094492063 creator A5017133102 @default.
• W2094492063 creator A5038591191 @default.
• W2094492063 creator A5039671431 @default.
• W2094492063 creator A5061531432 @default.
• W2094492063 creator A5062554444 @default.
• W2094492063 creator A5080648745 @default.
• W2094492063 creator A5082282983 @default.
• W2094492063 date "2000-04-01" @default.
• W2094492063 modified "2023-09-25" @default.
• W2094492063 title "Heparin Cofactor II Inhibits Thrombus Formation in a Rat Thrombosis Model" @default.
• W2094492063 cites W1493129807 @default.
• W2094492063 cites W1560801910 @default.
• W2094492063 cites W1576625825 @default.
• W2094492063 cites W196422501 @default.
• W2094492063 cites W1974882457 @default.
• W2094492063 cites W1979698812 @default.
• W2094492063 cites W1980059179 @default.
• W2094492063 cites W1982742307 @default.
• W2094492063 cites W2004679580 @default.
• W2094492063 cites W2021052435 @default.
• W2094492063 cites W2024342314 @default.
• W2094492063 cites W2028870588 @default.
• W2094492063 cites W2034863939 @default.
• W2094492063 cites W2051793587 @default.
• W2094492063 cites W2053233167 @default.
• W2094492063 cites W2053913287 @default.
• W2094492063 cites W2060097764 @default.
• W2094492063 cites W2073878148 @default.
• W2094492063 cites W2076364227 @default.
• W2094492063 cites W2093544782 @default.
• W2094492063 cites W2171082488 @default.
• W2094492063 cites W2276823679 @default.
• W2094492063 cites W2419354132 @default.
• W2094492063 cites W2462760285 @default.
• W2094492063 cites W3105556050 @default.
• W2094492063 cites W4327634928 @default.
• W2094492063 cites W80331072 @default.
• W2094492063 cites W85440235 @default.
• W2094492063 cites W92034159 @default.
• W2094492063 doi "https://doi.org/10.1016/s0049-3848(99)00201-7" @default.
• W2094492063 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10706937" @default.
• W2094492063 hasPublicationYear "2000" @default.
• W2094492063 type Work @default.
• W2094492063 sameAs 2094492063 @default.
• W2094492063 citedByCount "10" @default.
• W2094492063 countsByYear W20944920632012 @default.
• W2094492063 countsByYear W20944920632022 @default.
• W2094492063 crossrefType "journal-article" @default.
• W2094492063 hasAuthorship W2094492063A5017133102 @default.
• W2094492063 hasAuthorship W2094492063A5038591191 @default.
• W2094492063 hasAuthorship W2094492063A5039671431 @default.
• W2094492063 hasAuthorship W2094492063A5061531432 @default.
• W2094492063 hasAuthorship W2094492063A5062554444 @default.
• W2094492063 hasAuthorship W2094492063A5080648745 @default.
• W2094492063 hasAuthorship W2094492063A5082282983 @default.
• W2094492063 hasConcept C126322002 @default.
• W2094492063 hasConcept C144594695 @default.
• W2094492063 hasConcept C150903083 @default.
• W2094492063 hasConcept C185592680 @default.
• W2094492063 hasConcept C207001950 @default.
• W2094492063 hasConcept C2777292125 @default.
• W2094492063 hasConcept C2777557582 @default.
• W2094492063 hasConcept C2778162025 @default.
• W2094492063 hasConcept C2778261982 @default.
• W2094492063 hasConcept C2778382381 @default.
• W2094492063 hasConcept C2779026020 @default.
• W2094492063 hasConcept C2779612170 @default.
• W2094492063 hasConcept C2780868729 @default.
• W2094492063 hasConcept C2781362458 @default.
• W2094492063 hasConcept C55493867 @default.
• W2094492063 hasConcept C71924100 @default.
• W2094492063 hasConcept C86803240 @default.
• W2094492063 hasConcept C89560881 @default.
• W2094492063 hasConcept C98274493 @default.
• W2094492063 hasConceptScore W2094492063C126322002 @default.
• W2094492063 hasConceptScore W2094492063C144594695 @default.
• W2094492063 hasConceptScore W2094492063C150903083 @default.
• W2094492063 hasConceptScore W2094492063C185592680 @default.
• W2094492063 hasConceptScore W2094492063C207001950 @default.
• W2094492063 hasConceptScore W2094492063C2777292125 @default.
• W2094492063 hasConceptScore W2094492063C2777557582 @default.
• W2094492063 hasConceptScore W2094492063C2778162025 @default.
• W2094492063 hasConceptScore W2094492063C2778261982 @default.
• W2094492063 hasConceptScore W2094492063C2778382381 @default.
• W2094492063 hasConceptScore W2094492063C2779026020 @default.
• W2094492063 hasConceptScore W2094492063C2779612170 @default.
• W2094492063 hasConceptScore W2094492063C2780868729 @default.
• W2094492063 hasConceptScore W2094492063C2781362458 @default.
• W2094492063 hasConceptScore W2094492063C55493867 @default.
• W2094492063 hasConceptScore W2094492063C71924100 @default.
• W2094492063 hasConceptScore W2094492063C86803240 @default.
• W2094492063 hasConceptScore W2094492063C89560881 @default.
• W2094492063 hasConceptScore W2094492063C98274493 @default.
• W2094492063 hasIssue "1" @default.
• W2094492063 hasLocation W20944920631 @default.
• W2094492063 hasLocation W20944920632 @default.

• next