FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094493217> ?p ?o ?g. }

• W2094493217 endingPage "251" @default.
• W2094493217 startingPage "246" @default.
• W2094493217 abstract "Common fragile sites (CFSs) are loci that preferentially exhibit metaphase chromosome gaps and breaks after partial inhibition of DNA synthesis. The fragile site FRA3B, which lies within the FHIT tumor-suppressor gene, is a site of frequent heterozygous and homozygous deletions in many cancer cells and precancerous lesions. The great majority of FHIT and other CFS-associated gene rearrangements in tumors are submicroscopic, intralocus deletions of hundreds of kilobases that often result in inactivation of associated genes. Although CFS instability leads to chromosome gaps and breaks and translocations, there has been no direct evidence showing that CFS instability or replication stress can generate large submicroscopic deletions of the type seen in cancer cells. Here, we have produced FHIT/FRA3B deletions closely resembling those in tumors by exposing human–mouse chromosome 3 somatic hybrid cells to aphidicolin-mediated replication stress. Clonal cell populations were analyzed for deletions by using PCR, array comparative genomic hybridization (aCGH), and FISH. Thirteen percent to 23% of clones exhibited submicroscopic FHIT deletions spanning ≈200–600 kb within FRA3B. Chromosomes with FRA3B deletions exhibited significantly decreased fragility of this locus, with a 2- to 12-fold reduction in metaphase gaps and breaks compared with controls. Sequence analysis showed no regions of homology at breakpoints and suggests involvement of NHEJ in generating the deletions. Our results demonstrate that replication stress induces a remarkably high frequency of tumor-like microdeletions that reduce fragility at a CFS in cultured cells and suggests that similar conditions during tumor formation lead to intralocus deletion and inactivation of genes at CFSs and perhaps elsewhere in the genome." @default.
• W2094493217 created "2016-06-24" @default.
• W2094493217 creator A5002683233 @default.
• W2094493217 creator A5015832310 @default.
• W2094493217 creator A5017447734 @default.
• W2094493217 creator A5034935774 @default.
• W2094493217 creator A5057974062 @default.
• W2094493217 creator A5069770066 @default.
• W2094493217 date "2008-01-08" @default.
• W2094493217 modified "2023-10-03" @default.
• W2094493217 title "Replication stress induces tumor-like microdeletions in <i>FHIT</i> /FRA3B" @default.
• W2094493217 cites W126231498 @default.
• W2094493217 cites W144570808 @default.
• W2094493217 cites W1560247953 @default.
• W2094493217 cites W1571094543 @default.
• W2094493217 cites W1899791338 @default.
• W2094493217 cites W1966502640 @default.
• W2094493217 cites W1967743500 @default.
• W2094493217 cites W1969817641 @default.
• W2094493217 cites W1970474771 @default.
• W2094493217 cites W1974993967 @default.
• W2094493217 cites W1992036233 @default.
• W2094493217 cites W2008958153 @default.
• W2094493217 cites W2013000007 @default.
• W2094493217 cites W2015416439 @default.
• W2094493217 cites W2022293814 @default.
• W2094493217 cites W2025966409 @default.
• W2094493217 cites W2033418072 @default.
• W2094493217 cites W2034649293 @default.
• W2094493217 cites W2042879563 @default.
• W2094493217 cites W2051311335 @default.
• W2094493217 cites W2057902837 @default.
• W2094493217 cites W2059971436 @default.
• W2094493217 cites W2061445402 @default.
• W2094493217 cites W2072131245 @default.
• W2094493217 cites W2082559623 @default.
• W2094493217 cites W2084964666 @default.
• W2094493217 cites W2085163111 @default.
• W2094493217 cites W2088858763 @default.
• W2094493217 cites W2099978872 @default.
• W2094493217 cites W2100725331 @default.
• W2094493217 cites W2101185225 @default.
• W2094493217 cites W2102570250 @default.
• W2094493217 cites W2108742137 @default.
• W2094493217 cites W2108925373 @default.
• W2094493217 cites W2114728791 @default.
• W2094493217 cites W2123077135 @default.
• W2094493217 cites W2124102021 @default.
• W2094493217 cites W2126190124 @default.
• W2094493217 cites W2130679565 @default.
• W2094493217 cites W2137259838 @default.
• W2094493217 cites W2157709503 @default.
• W2094493217 cites W2159686532 @default.
• W2094493217 cites W2163962436 @default.
• W2094493217 cites W2317540788 @default.
• W2094493217 cites W2434637644 @default.
• W2094493217 cites W4231845372 @default.
• W2094493217 doi "https://doi.org/10.1073/pnas.0708097105" @default.
• W2094493217 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2224195" @default.
• W2094493217 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18162546" @default.
• W2094493217 hasPublicationYear "2008" @default.
• W2094493217 type Work @default.
• W2094493217 sameAs 2094493217 @default.
• W2094493217 citedByCount "107" @default.
• W2094493217 countsByYear W20944932172012 @default.
• W2094493217 countsByYear W20944932172013 @default.
• W2094493217 countsByYear W20944932172014 @default.
• W2094493217 countsByYear W20944932172015 @default.
• W2094493217 countsByYear W20944932172016 @default.
• W2094493217 countsByYear W20944932172017 @default.
• W2094493217 countsByYear W20944932172018 @default.
• W2094493217 countsByYear W20944932172019 @default.
• W2094493217 countsByYear W20944932172020 @default.
• W2094493217 countsByYear W20944932172021 @default.
• W2094493217 countsByYear W20944932172022 @default.
• W2094493217 crossrefType "journal-article" @default.
• W2094493217 hasAuthorship W2094493217A5002683233 @default.
• W2094493217 hasAuthorship W2094493217A5015832310 @default.
• W2094493217 hasAuthorship W2094493217A5017447734 @default.
• W2094493217 hasAuthorship W2094493217A5034935774 @default.
• W2094493217 hasAuthorship W2094493217A5057974062 @default.
• W2094493217 hasAuthorship W2094493217A5069770066 @default.
• W2094493217 hasBestOaLocation W20944932172 @default.
• W2094493217 hasConcept C104317684 @default.
• W2094493217 hasConcept C140752955 @default.
• W2094493217 hasConcept C143425029 @default.
• W2094493217 hasConcept C143589142 @default.
• W2094493217 hasConcept C153911025 @default.
• W2094493217 hasConcept C178169997 @default.
• W2094493217 hasConcept C179185449 @default.
• W2094493217 hasConcept C180754005 @default.
• W2094493217 hasConcept C2776253266 @default.
• W2094493217 hasConcept C2778264664 @default.
• W2094493217 hasConcept C2778512757 @default.
• W2094493217 hasConcept C2780646079 @default.
• W2094493217 hasConcept C2780770488 @default.
• W2094493217 hasConcept C30481170 @default.
• W2094493217 hasConcept C54355233 @default.

• next