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- W2094493931 abstract "The effects of differential housing on T-helper (TH) cell activation were investigated. BALB/c and C57B1/6 male mice housed 1 or 4 per cage were administered three i.p. injections of keyhole limpet hemocyanin (KLH) over several weeks. Effects of differential housing on in vitro antigen-specific interleukin (IL)-2 (a TH1 cell derived cytokine) and IL-4 (a TH2 cell derived cytokine) production were observed. BALB/c mice housed alone produced significantly more IL-4 than BALB/c mice housed in groups. C57B1/6 mice housed alone produced significantly more IL-2 than C57B1/6 mice housed in groups. Differential housing did not influence either IL-2 production among BALB/c mice or IL-4 production among C57B1/6 mice. These data demonstrate that environmental conditions can influence cytokine production by both TH-1 dominant (C57B1/6) and TH-2 dominant (BALB/c) mice." @default.
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- W2094493931 date "1994-01-01" @default.
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- W2094493931 title "Quantitative differences in interleukin-2 and interleukin-4 production by antigen-stimulated splenocytes from individually- and group-housed mice" @default.
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- W2094493931 doi "https://doi.org/10.1016/0024-3205(94)00562-1" @default.
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