Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094507259> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2094507259 endingPage "1058" @default.
- W2094507259 startingPage "1052" @default.
- W2094507259 abstract "A highly sensitive, rapid assay method has been developed and validated for the estimation of S-citalopram (S-CPM) in rat plasma with liquid chromatography coupled to tandem mass spectrometry with electrospray ionization in the positive-ion mode. The assay procedure involves a simple liquid–liquid extraction of S-CPM and phenacetin (internal standard, IS) from rat plasma with t-butyl methyl ether. Chromatographic separation was operated with 0.2% formic acid:acetonitrile (20:80, v/v) at a flow rate of 0.50 mL/min on a Symmetry Shield RP18 column with a total run time of 3.0 min. The MS/MS ion transitions monitored were 325.26 → 109.10 for S-CPM and 180.10 → 110.10 for IS. Method validation and pre-clinical sample analysis were performed as per FDA guidelines and the results met the acceptance criteria. The lower limit of quantitation achieved was 0.5 ng/mL and the linearity was observed from 0.5 to 5000 ng/mL. The intra- and inter-day precisions were in the range of 1.14–5.56 and 0.25–12.3%, respectively. This novel method has been applied to a pharmacokinetic study and to estimate brain-to-plasma ratio of S-CPM in rats. Copyright © 2010 John Wiley & Sons, Ltd." @default.
- W2094507259 created "2016-06-24" @default.
- W2094507259 creator A5038266306 @default.
- W2094507259 creator A5053360518 @default.
- W2094507259 creator A5057389477 @default.
- W2094507259 creator A5083166265 @default.
- W2094507259 date "2010-09-10" @default.
- W2094507259 modified "2023-09-25" @default.
- W2094507259 title "A highly sensitive LC-MS/MS method for the determination of S-citalopram in rat plasma: application to a pharmacokinetic study in rats" @default.
- W2094507259 cites W106465623 @default.
- W2094507259 cites W1976338435 @default.
- W2094507259 cites W1983309015 @default.
- W2094507259 cites W1989815682 @default.
- W2094507259 cites W2007455664 @default.
- W2094507259 cites W2104291200 @default.
- W2094507259 cites W2169196377 @default.
- W2094507259 doi "https://doi.org/10.1002/bmc.1405" @default.
- W2094507259 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20352615" @default.
- W2094507259 hasPublicationYear "2010" @default.
- W2094507259 type Work @default.
- W2094507259 sameAs 2094507259 @default.
- W2094507259 citedByCount "8" @default.
- W2094507259 countsByYear W20945072592012 @default.
- W2094507259 countsByYear W20945072592013 @default.
- W2094507259 countsByYear W20945072592014 @default.
- W2094507259 countsByYear W20945072592017 @default.
- W2094507259 countsByYear W20945072592018 @default.
- W2094507259 countsByYear W20945072592019 @default.
- W2094507259 crossrefType "journal-article" @default.
- W2094507259 hasAuthorship W2094507259A5038266306 @default.
- W2094507259 hasAuthorship W2094507259A5053360518 @default.
- W2094507259 hasAuthorship W2094507259A5057389477 @default.
- W2094507259 hasAuthorship W2094507259A5083166265 @default.
- W2094507259 hasConcept C112705442 @default.
- W2094507259 hasConcept C119128265 @default.
- W2094507259 hasConcept C162356407 @default.
- W2094507259 hasConcept C185592680 @default.
- W2094507259 hasConcept C194451485 @default.
- W2094507259 hasConcept C2775922563 @default.
- W2094507259 hasConcept C2777379063 @default.
- W2094507259 hasConcept C31827203 @default.
- W2094507259 hasConcept C40684141 @default.
- W2094507259 hasConcept C43617362 @default.
- W2094507259 hasConcept C4725764 @default.
- W2094507259 hasConcept C64489805 @default.
- W2094507259 hasConcept C71043704 @default.
- W2094507259 hasConcept C71924100 @default.
- W2094507259 hasConcept C98274493 @default.
- W2094507259 hasConceptScore W2094507259C112705442 @default.
- W2094507259 hasConceptScore W2094507259C119128265 @default.
- W2094507259 hasConceptScore W2094507259C162356407 @default.
- W2094507259 hasConceptScore W2094507259C185592680 @default.
- W2094507259 hasConceptScore W2094507259C194451485 @default.
- W2094507259 hasConceptScore W2094507259C2775922563 @default.
- W2094507259 hasConceptScore W2094507259C2777379063 @default.
- W2094507259 hasConceptScore W2094507259C31827203 @default.
- W2094507259 hasConceptScore W2094507259C40684141 @default.
- W2094507259 hasConceptScore W2094507259C43617362 @default.
- W2094507259 hasConceptScore W2094507259C4725764 @default.
- W2094507259 hasConceptScore W2094507259C64489805 @default.
- W2094507259 hasConceptScore W2094507259C71043704 @default.
- W2094507259 hasConceptScore W2094507259C71924100 @default.
- W2094507259 hasConceptScore W2094507259C98274493 @default.
- W2094507259 hasIssue "10" @default.
- W2094507259 hasLocation W20945072591 @default.
- W2094507259 hasLocation W20945072592 @default.
- W2094507259 hasOpenAccess W2094507259 @default.
- W2094507259 hasPrimaryLocation W20945072591 @default.
- W2094507259 hasRelatedWork W1277187992 @default.
- W2094507259 hasRelatedWork W1558772439 @default.
- W2094507259 hasRelatedWork W2008473017 @default.
- W2094507259 hasRelatedWork W2148112117 @default.
- W2094507259 hasRelatedWork W2348641065 @default.
- W2094507259 hasRelatedWork W2392271453 @default.
- W2094507259 hasRelatedWork W2791978427 @default.
- W2094507259 hasRelatedWork W2979742567 @default.
- W2094507259 hasRelatedWork W4225985420 @default.
- W2094507259 hasRelatedWork W4238213830 @default.
- W2094507259 hasVolume "24" @default.
- W2094507259 isParatext "false" @default.
- W2094507259 isRetracted "false" @default.
- W2094507259 magId "2094507259" @default.
- W2094507259 workType "article" @default.