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- W2094519323 endingPage "170" @default.
- W2094519323 startingPage "161" @default.
- W2094519323 abstract "S-Adenosylmethionine (SAM) is a versatile small molecule used in many biological reactions. This review focuses on the mechanistic consideration of SAM-dependent methylation and 3-amino-3-carboxypropylation reactions. Special emphasis is given to methylation and 3-amino-3-carboxypropylation of carbon atoms, for which both nucleophilic mechanisms and radical mechanisms are used, depending on the specific enzymatic reactions. What is the logic behind Nature's choice of different reaction mechanisms? Here I aim to rationalize the choice of different reaction mechanisms in SAM-dependent alkylation reaction by analyzing a few enzymatic reactions in depth. These reactions include SAM-dependent cyclopropane fatty acid synthesis, DNA cytosine methylation, RNA adenosine C2 and C8 methylation, and 3-amino-3-carboxypropylation involved in diphthamide biosynthesis and wybutosine biosynthesis." @default.
- W2094519323 created "2016-06-24" @default.
- W2094519323 creator A5001339258 @default.
- W2094519323 date "2011-12-01" @default.
- W2094519323 modified "2023-09-23" @default.
- W2094519323 title "S-Adenosylmethionine-dependent alkylation reactions: When are radical reactions used?" @default.
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- W2094519323 doi "https://doi.org/10.1016/j.bioorg.2011.06.001" @default.
- W2094519323 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3188380" @default.
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- W2094519323 hasPublicationYear "2011" @default.
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