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- W2094527845 abstract "Seven children were diagnosed as having an emotional cause for growth failure. Pretreatment growth hormone secretion profiles during sleep were analysed using PULSAR. Mean (± SD) growth hormone concentration was 10.9 (4.4) mU/1, mean peak 19.6 (6.7) mU/1 and the peak-to-peak interval 147 (108) min. Mean (SEM) IGF-1 was 1.08 (0.31). The seven children received a six-month course of recombinant growth hormone in a double-blind, crossover study using a dose of 1.2 U/kg/week (28 U/ m2/week). Daily placebo injections were given for the other six-month epoch, with a one month washout period. The mean (SEM) growth velocity SD score after growth hormone administration was +4.66 (1.88) and after placebo -0.60 (0.69), each value being greater than the pretreatment value of -2.32 (0.122) (p < 0.0001 on analysis of variance). The change in IGF-1 during growth hormone treatment was not significant. No significant changes in food energy or protein intake occurred." @default.
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- W2094527845 date "1992-04-01" @default.
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- W2094527845 title "Psychosocial growth failure: a positive response to growth hormone and placebo" @default.
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- W2094527845 doi "https://doi.org/10.1111/j.1651-2227.1992.tb12235.x" @default.
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