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• W2094529400 abstract "FIP-fve is a fungal immunomodulatory protein purified from Flammulina velutipes, an edible golden needle mushroom thought to possess potent immunomodulatory properties. When examined for its effects on lymphocytes, FIP-fve exhibited potent mitogenic effects on human peripheral blood lymphocytes, inducing G1/G0 to S phase proliferation. T cells activated by FIP-fve show significant production and secretion of interferon-γ (IFN-γ) associated with intercellular adhesion molecule 1 expression but low detectable levels of interleukin-4 in vitro or in vivo. However, SB203580, the p38 mitogen-activated protein kinase (p38 MAPK) inhibitor, can fully abolish the production of IFN-γ induced by FIP-fve. At the same time, SB203580 only partially prevents the lymphocytes from progressing from G1 to S phase of the cell cycle. These findings demonstrate that FIP-fve is a potent T-cell activator, mediating its effects via cytokine regulation of p38 MAPK. The immunoprophylatic effects of FIP-fve in Th2-mediated allergic anaphylaxis are believed to be associated with the ability of FIP-fve to enhance activation of IFN-γ-releasing Th1 cells. Keywords: Fungal immunomodulatory protein; IFN-γ; p38" @default.
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• W2094529400 date "2004-04-10" @default.
• W2094529400 modified "2023-09-30" @default.
• W2094529400 title "Fungal Immunomodulatory Protein from <i>Flammulina velutipes</i> Induces Interferon-γ Production through p38 Mitogen-Activated Protein Kinase Signaling Pathway" @default.
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• W2094529400 doi "https://doi.org/10.1021/jf034556s" @default.
• W2094529400 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15113182" @default.
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