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- W2094529440 abstract "A formulation containing an antiinflammatory agent (diclofenac sodium), two inert matrices (ethylcellulose and polyvinyl chloride) and two lubricants (magnesium stearate and talc) was optimized by a double compression processIn a first stage, preliminary trials were performed in order to study the effect of lubricants added before and after precompressionAn Hadamard matrix H(8) was applied to estimate the main effects of four parameters: applied force at the upper punch (UPF) during precompression, particle size range after grinding, UPF during the final compression and concentration of ethylcellulose added before the final compressionFollowing the Hadamard matrix, a factorial design 22 was built. The complete linear models were fitted by regression for each response reflecting the compression behaviour and dissolution kineticsIn an optimal point, the validation was carried out with the area under the dissolution curve, being the major response to be optimizedThe dissolution curves were well fitted by the Weibull distribution" @default.
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- W2094529440 date "1989-01-01" @default.
- W2094529440 modified "2023-09-27" @default.
- W2094529440 title "Statistical Optimization of a Controlled Release Formulation Obtained by a Double Compression Process: Application of an Hadamard Matrix and a Factorial Design" @default.
- W2094529440 cites W1983734200 @default.
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- W2094529440 doi "https://doi.org/10.3109/03639048909052539" @default.
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