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• W2094530557 abstract "Abstract The effect of diisopropyl 1,3-dithiol-2-ylidenemalonate (NKK-105) on microsomal electron transport systems in relation to drug oxidation was studied in rat liver. A single oral dose (250 mg/kg) of NKK-105 increased the ratio of liver to body weight, the microsomal protein content, the cytochrome b 5 content, and the NADPH cytochrome c reductase activity at 24–48 hr after drug administration. The cytochrome P-450 content was decreased at 2–6 hr and slightly increased at 24–48 hr after drug administration. Upon daily administration of NKK-105 at a dose of 250 mg · kg −1 · day −1 for 21 days, cytochrome b 5 content and NADPH cytochrome c reductase activity were increased, but cytochrome P-450 content and NADH cytochrome b 5 reductase activity remained unchanged. Despite the increase of NADPH cytochrome c reductase activity, NADPH-dependent lipid peroxidation tended to decrease rather than increase. NADPH stearoyl-CoA desaturase activity increased prior to the increase of cytochrome b 5 . Benzphetamine N -demethylase and p -nitroanisole O -demethylase activities were enhanced, accompanied by an increase of cytochrome b 5 . Aniline hydroxylase activity was decreased by NKK-105 administration. These results indicate that the induction pattern of liver microsomal electron transport systems by NKK-105 is characteristic." @default.
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• W2094530557 date "1981-10-01" @default.
• W2094530557 modified "2023-09-25" @default.
• W2094530557 title "Further studies on the in vivo effect of diisopropyl 1,3-dithiol-2-ylidenemalonate (NKK-105) on the liver microsomal drug oxidation system in rats" @default.
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• W2094530557 doi "https://doi.org/10.1016/0006-2952(81)90412-3" @default.
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