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• W2094536764 abstract "The administration of chemicals at the maximum tolerated dose (MTD) in standard animal cancer tests is postulated to increase cell division (mitogenesis), which in turn increases rates of mutagenesis and thus carcinogenesis. The animal data are consistent with this mechanism, because a high proportion--about half--of all chemicals tested (whether natural or synthetic) are indeed rodent carcinogens. We conclude that at the low doses of most human exposures, where cell killing does not occur, the hazards to humans of rodent carcinogens may be much lower than is commonly assumed." @default.
• W2094536764 created "2016-06-24" @default.
• W2094536764 creator A5017410316 @default.
• W2094536764 creator A5047067531 @default.
• W2094536764 date "1990-10-01" @default.
• W2094536764 modified "2023-10-15" @default.
• W2094536764 title "Chemical carcinogenesis: too many rodent carcinogens." @default.
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• W2094536764 doi "https://doi.org/10.1073/pnas.87.19.7772" @default.
• W2094536764 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/54830" @default.
• W2094536764 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2217209" @default.
• W2094536764 hasPublicationYear "1990" @default.
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