Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094549690> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2094549690 endingPage "59" @default.
- W2094549690 startingPage "53" @default.
- W2094549690 abstract "To explore the feasibility and potential advantages of PBSC in allogeneic transplantation, we grafted 24 patients (age 16-57, median 37) with different hematologic diseases (ALL = 10, AML = 5, MM = 4, NHL = 2, CML = 1, MDS = 1, AA = 1), 23 HLA-identical to their siblings and 1 partially matched. Cells were collected from donors by apheresis after G-CSF 10 to 16 mg/kg/day for 4 to 5 days, and stored at 4 degrees C until infusion. The patients were conditioned with chemotherapy regimens including busulfan and cyclophosphamide in the majority of cases and received GVHD prophylaxis with CSA-MTX in all but two. The graft consisted of PBSC alone, with a median of 143.5 (range 18.1-358.9) x 10(4)/kg CFU-GM, 9.0 (range 3.3-18.0) x 10(6)/kg CD34+ cells and 2.8 (range 1.2 to 8.6) x 10(8)/kg CD3+ and cells. An ANC >0.0.5 x 10(9)/L was recovered on (median) day 13 (range 11-17), and a platelet count >50 x 10(9)/L on (median) day 13 (range 12-55) post graft. There was no correlation between CD34+ cells or CFU-GM number in the inoculum and time to hematologic reconstitution. Acute GVHD (grade II-IV) occurred in 10 out of 22 (45%), chronic GVHD in 10 out of 18 evaluable (55%) patients. We found no relationship between occurrence of acute or chronic GVHD and number of CD3+ cells in the graft. Four patients relapsed and 7 died after transplantation. Fifteen patients are currently alive and disease-free 67 to 710 (median 286) days from the graft. Allogeneic transplantation with unmanipulated PBSC ensures a fast and stable engraftment. Acute GVHD incidence and severity seems comparable to that of bone marrow transplantation, but there may be an increase in chronic GVHD, mainly of the extensive form." @default.
- W2094549690 created "2016-06-24" @default.
- W2094549690 creator A5000636320 @default.
- W2094549690 creator A5025143604 @default.
- W2094549690 creator A5027526895 @default.
- W2094549690 creator A5030392971 @default.
- W2094549690 creator A5049594325 @default.
- W2094549690 creator A5059515934 @default.
- W2094549690 creator A5077108337 @default.
- W2094549690 creator A5087017066 @default.
- W2094549690 creator A5089924339 @default.
- W2094549690 date "1997-01-01" @default.
- W2094549690 modified "2023-10-14" @default.
- W2094549690 title "Transplantation of Unmanipulated Allogeneic PBSC: Preliminary Report on 24 Patients" @default.
- W2094549690 cites W1256794680 @default.
- W2094549690 cites W190201512 @default.
- W2094549690 cites W1986693381 @default.
- W2094549690 cites W1993507283 @default.
- W2094549690 cites W2053951805 @default.
- W2094549690 cites W2093687787 @default.
- W2094549690 cites W2157651001 @default.
- W2094549690 cites W2159624800 @default.
- W2094549690 cites W2240289126 @default.
- W2094549690 cites W2301167541 @default.
- W2094549690 cites W2337969406 @default.
- W2094549690 cites W2417849984 @default.
- W2094549690 cites W29728402 @default.
- W2094549690 cites W4245276353 @default.
- W2094549690 cites W44995847 @default.
- W2094549690 doi "https://doi.org/10.3109/10428199709058600" @default.
- W2094549690 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9570680" @default.
- W2094549690 hasPublicationYear "1997" @default.
- W2094549690 type Work @default.
- W2094549690 sameAs 2094549690 @default.
- W2094549690 citedByCount "2" @default.
- W2094549690 crossrefType "journal-article" @default.
- W2094549690 hasAuthorship W2094549690A5000636320 @default.
- W2094549690 hasAuthorship W2094549690A5025143604 @default.
- W2094549690 hasAuthorship W2094549690A5027526895 @default.
- W2094549690 hasAuthorship W2094549690A5030392971 @default.
- W2094549690 hasAuthorship W2094549690A5049594325 @default.
- W2094549690 hasAuthorship W2094549690A5059515934 @default.
- W2094549690 hasAuthorship W2094549690A5077108337 @default.
- W2094549690 hasAuthorship W2094549690A5087017066 @default.
- W2094549690 hasAuthorship W2094549690A5089924339 @default.
- W2094549690 hasConcept C10205521 @default.
- W2094549690 hasConcept C126322002 @default.
- W2094549690 hasConcept C141071460 @default.
- W2094549690 hasConcept C203014093 @default.
- W2094549690 hasConcept C2776694085 @default.
- W2094549690 hasConcept C2776738589 @default.
- W2094549690 hasConcept C2776755627 @default.
- W2094549690 hasConcept C2780611847 @default.
- W2094549690 hasConcept C28328180 @default.
- W2094549690 hasConcept C2911091166 @default.
- W2094549690 hasConcept C54355233 @default.
- W2094549690 hasConcept C71924100 @default.
- W2094549690 hasConcept C86803240 @default.
- W2094549690 hasConcept C89560881 @default.
- W2094549690 hasConcept C90924648 @default.
- W2094549690 hasConceptScore W2094549690C10205521 @default.
- W2094549690 hasConceptScore W2094549690C126322002 @default.
- W2094549690 hasConceptScore W2094549690C141071460 @default.
- W2094549690 hasConceptScore W2094549690C203014093 @default.
- W2094549690 hasConceptScore W2094549690C2776694085 @default.
- W2094549690 hasConceptScore W2094549690C2776738589 @default.
- W2094549690 hasConceptScore W2094549690C2776755627 @default.
- W2094549690 hasConceptScore W2094549690C2780611847 @default.
- W2094549690 hasConceptScore W2094549690C28328180 @default.
- W2094549690 hasConceptScore W2094549690C2911091166 @default.
- W2094549690 hasConceptScore W2094549690C54355233 @default.
- W2094549690 hasConceptScore W2094549690C71924100 @default.
- W2094549690 hasConceptScore W2094549690C86803240 @default.
- W2094549690 hasConceptScore W2094549690C89560881 @default.
- W2094549690 hasConceptScore W2094549690C90924648 @default.
- W2094549690 hasIssue "sup1" @default.
- W2094549690 hasLocation W20945496901 @default.
- W2094549690 hasLocation W20945496902 @default.
- W2094549690 hasOpenAccess W2094549690 @default.
- W2094549690 hasPrimaryLocation W20945496901 @default.
- W2094549690 hasRelatedWork W2037178714 @default.
- W2094549690 hasRelatedWork W2049808065 @default.
- W2094549690 hasRelatedWork W2053445678 @default.
- W2094549690 hasRelatedWork W2072919564 @default.
- W2094549690 hasRelatedWork W2402227730 @default.
- W2094549690 hasRelatedWork W2415351737 @default.
- W2094549690 hasRelatedWork W2415933091 @default.
- W2094549690 hasRelatedWork W2466043989 @default.
- W2094549690 hasRelatedWork W2560002354 @default.
- W2094549690 hasRelatedWork W3173436519 @default.
- W2094549690 hasVolume "26" @default.
- W2094549690 isParatext "false" @default.
- W2094549690 isRetracted "false" @default.
- W2094549690 magId "2094549690" @default.
- W2094549690 workType "article" @default.