FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094554599> ?p ?o ?g. }

• W2094554599 endingPage "33" @default.
• W2094554599 startingPage "27" @default.
• W2094554599 abstract "A single nucleotide polymorphism in the human COMT (catechol-O-methyltransferase) gene has been associated with increased risk for breast cancer and several CNS diseases and disorders. The G to A polymorphism causes a valine (val) to methionine (met) substitution at codon 108 soluble - (S)/158 membrane - (MB)-COMT, generating alleles encoding high and low-activity forms of the enzyme, COMTH and COMTL, respectively. Tissues and cells with a COMTLL genotype have decreased COMT activity compared to COMTHH cells. Previously, we reported that the decreased activity was due to decreased amounts of S-COMTL protein in human hepatocytes. In this study, we investigated the role of S-COMT protein synthesis and turnover as determinates of reduced COMT protein in COMTLL compared to COMTHH cells. No association between S-COMT protein synthesis and COMT genotype was detected. Using a pulse-chase protocol, the half-life of S-COMTH was determined to be 4.7 days, which was considerably longer than expected from the half-lives of other phase 2 enzyme proteins. The half-life of S-COMTL compared to S-COMTH protein was significantly shorter at 3.0 days, but the difference was affected by the medium used during the chase period. These results suggest that increased turnover may contribute to reduced COMT activity in cells and tissues from COMTLL individuals. Subtle differences appear to be able to affect the stability of the S-COMTL protein, and this may contribute to the differences observed in epidemiological studies on the association of this polymorphism with breast cancer risk." @default.
• W2094554599 created "2016-06-24" @default.
• W2094554599 creator A5005242571 @default.
• W2094554599 creator A5089963590 @default.
• W2094554599 date "2008-01-01" @default.
• W2094554599 modified "2023-09-28" @default.
• W2094554599 title "Catechol-O-methyltransferase: Effects of the val108met polymorphism on protein turnover in human cells" @default.
• W2094554599 cites W1925723678 @default.
• W2094554599 cites W1976889696 @default.
• W2094554599 cites W1982167929 @default.
• W2094554599 cites W1984038669 @default.
• W2094554599 cites W1986457078 @default.
• W2094554599 cites W1988550602 @default.
• W2094554599 cites W1989292149 @default.
• W2094554599 cites W1997343027 @default.
• W2094554599 cites W1997499972 @default.
• W2094554599 cites W2006373408 @default.
• W2094554599 cites W2009787864 @default.
• W2094554599 cites W2015530623 @default.
• W2094554599 cites W2021040301 @default.
• W2094554599 cites W2026989222 @default.
• W2094554599 cites W2041056390 @default.
• W2094554599 cites W2049595315 @default.
• W2094554599 cites W2053589861 @default.
• W2094554599 cites W2054856852 @default.
• W2094554599 cites W2058971771 @default.
• W2094554599 cites W2072955271 @default.
• W2094554599 cites W2076923580 @default.
• W2094554599 cites W2079424406 @default.
• W2094554599 cites W2086360865 @default.
• W2094554599 cites W2149761960 @default.
• W2094554599 cites W2162001627 @default.
• W2094554599 cites W2165422066 @default.
• W2094554599 cites W2169270672 @default.
• W2094554599 doi "https://doi.org/10.1016/j.bbagen.2007.10.002" @default.
• W2094554599 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2198850" @default.
• W2094554599 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17980711" @default.
• W2094554599 hasPublicationYear "2008" @default.
• W2094554599 type Work @default.
• W2094554599 sameAs 2094554599 @default.
• W2094554599 citedByCount "15" @default.
• W2094554599 countsByYear W20945545992012 @default.
• W2094554599 countsByYear W20945545992013 @default.
• W2094554599 countsByYear W20945545992014 @default.
• W2094554599 countsByYear W20945545992016 @default.
• W2094554599 countsByYear W20945545992017 @default.
• W2094554599 countsByYear W20945545992019 @default.
• W2094554599 countsByYear W20945545992020 @default.
• W2094554599 countsByYear W20945545992021 @default.
• W2094554599 crossrefType "journal-article" @default.
• W2094554599 hasAuthorship W2094554599A5005242571 @default.
• W2094554599 hasAuthorship W2094554599A5089963590 @default.
• W2094554599 hasBestOaLocation W20945545992 @default.
• W2094554599 hasConcept C104317684 @default.
• W2094554599 hasConcept C134018914 @default.
• W2094554599 hasConcept C135763542 @default.
• W2094554599 hasConcept C153209595 @default.
• W2094554599 hasConcept C153911025 @default.
• W2094554599 hasConcept C180754005 @default.
• W2094554599 hasConcept C181199279 @default.
• W2094554599 hasConcept C185361966 @default.
• W2094554599 hasConcept C195580219 @default.
• W2094554599 hasConcept C2777573094 @default.
• W2094554599 hasConcept C2780912031 @default.
• W2094554599 hasConcept C28212737 @default.
• W2094554599 hasConcept C33288867 @default.
• W2094554599 hasConcept C3675279 @default.
• W2094554599 hasConcept C515207424 @default.
• W2094554599 hasConcept C55493867 @default.
• W2094554599 hasConcept C86803240 @default.
• W2094554599 hasConcept C91965660 @default.
• W2094554599 hasConceptScore W2094554599C104317684 @default.
• W2094554599 hasConceptScore W2094554599C134018914 @default.
• W2094554599 hasConceptScore W2094554599C135763542 @default.
• W2094554599 hasConceptScore W2094554599C153209595 @default.
• W2094554599 hasConceptScore W2094554599C153911025 @default.
• W2094554599 hasConceptScore W2094554599C180754005 @default.
• W2094554599 hasConceptScore W2094554599C181199279 @default.
• W2094554599 hasConceptScore W2094554599C185361966 @default.
• W2094554599 hasConceptScore W2094554599C195580219 @default.
• W2094554599 hasConceptScore W2094554599C2777573094 @default.
• W2094554599 hasConceptScore W2094554599C2780912031 @default.
• W2094554599 hasConceptScore W2094554599C28212737 @default.
• W2094554599 hasConceptScore W2094554599C33288867 @default.
• W2094554599 hasConceptScore W2094554599C3675279 @default.
• W2094554599 hasConceptScore W2094554599C515207424 @default.
• W2094554599 hasConceptScore W2094554599C55493867 @default.
• W2094554599 hasConceptScore W2094554599C86803240 @default.
• W2094554599 hasConceptScore W2094554599C91965660 @default.
• W2094554599 hasIssue "1" @default.
• W2094554599 hasLocation W20945545991 @default.
• W2094554599 hasLocation W20945545992 @default.
• W2094554599 hasLocation W20945545993 @default.
• W2094554599 hasLocation W20945545994 @default.
• W2094554599 hasOpenAccess W2094554599 @default.
• W2094554599 hasPrimaryLocation W20945545991 @default.
• W2094554599 hasRelatedWork W1511048503 @default.
• W2094554599 hasRelatedWork W2025415714 @default.

• next