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- W2094559319 abstract "Many investigators believe that systemic lupus erythematosus is an autoimmune disease, perhaps caused by inadequate suppressor T lymphocyte activity, which permits the activation of autoantibody producing B lymphocytes. This paper discusses the testable hypothesis that a superoxide-generating, chromosome aberration-inducing factor (clastogenic factor), present in the lymphocytes of lupus patients but absent from normals, is responsible for such a suppressor cell defect. Superoxide or activated oxygen species derived from it, such as hydroxyl radical, may be the molecular mediators of CF activity." @default.
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- W2094559319 date "1982-06-01" @default.
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- W2094559319 title "The pathogenesis of systemic lupus erythematosus" @default.
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- W2094559319 doi "https://doi.org/10.1016/0306-9877(82)90047-0" @default.
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