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• W2094569719 endingPage "401.e10" @default.
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• W2094569719 abstract "Objective The purpose of this study was to calculate nationally representative, population-based estimates of maternal and neonatal risks in triplet and quadruplet pregnancies compared with twin pregnancies. Study Design The study population included 316,696 twin, 12,193 triplet, and 778 quadruplet pregnancies from the 1995-2000 Matched Multiple Birth Data Set. Adjusted odds ratios (AORs) and 95% CIs estimated the risk of complications and were controlled for maternal age, race, parity, and smoking status. Results Compared with mothers of twins, mothers of triplets and quadruplets were more likely to be diagnosed with preterm premature rupture of membranes (AORs, 1.53, 1.74, respectively), pregnancy-associated hypertension (AORs, 1.22, 1.27), and excessive bleeding (AORs, 1.50, 2.22), to require tocolysis (AORs, 2.85, 5.03), and to be delivered by cesarean (AORs, 6.55, 7.38) at <29 weeks of gestation (AORs, 3.76, 7.96), and to have ≥1 infants die (AORs, 3.02, 4.07). Conclusion Triplet and quadruplet pregnancies have significantly higher risks than twin pregnancies for most maternal and neonatal complications. Maternal anthropometric, nutritional, and previous reproductive factors may be particularly important in the reduction of these excess risks and improvement of outcomes in multiple births. The purpose of this study was to calculate nationally representative, population-based estimates of maternal and neonatal risks in triplet and quadruplet pregnancies compared with twin pregnancies. The study population included 316,696 twin, 12,193 triplet, and 778 quadruplet pregnancies from the 1995-2000 Matched Multiple Birth Data Set. Adjusted odds ratios (AORs) and 95% CIs estimated the risk of complications and were controlled for maternal age, race, parity, and smoking status. Compared with mothers of twins, mothers of triplets and quadruplets were more likely to be diagnosed with preterm premature rupture of membranes (AORs, 1.53, 1.74, respectively), pregnancy-associated hypertension (AORs, 1.22, 1.27), and excessive bleeding (AORs, 1.50, 2.22), to require tocolysis (AORs, 2.85, 5.03), and to be delivered by cesarean (AORs, 6.55, 7.38) at <29 weeks of gestation (AORs, 3.76, 7.96), and to have ≥1 infants die (AORs, 3.02, 4.07). Triplet and quadruplet pregnancies have significantly higher risks than twin pregnancies for most maternal and neonatal complications. Maternal anthropometric, nutritional, and previous reproductive factors may be particularly important in the reduction of these excess risks and improvement of outcomes in multiple births." @default.
• W2094569719 created "2016-06-24" @default.
• W2094569719 creator A5049065825 @default.
• W2094569719 creator A5075841796 @default.
• W2094569719 date "2008-04-01" @default.
• W2094569719 modified "2023-10-01" @default.
• W2094569719 title "Maternal morbidity and infant death in twin vs triplet and quadruplet pregnancies" @default.
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• W2094569719 doi "https://doi.org/10.1016/j.ajog.2007.10.785" @default.
• W2094569719 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18177828" @default.
• W2094569719 hasPublicationYear "2008" @default.
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