FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094588193> ?p ?o ?g. }

• W2094588193 endingPage "2628" @default.
• W2094588193 startingPage "2622" @default.
• W2094588193 abstract "Radiolabeled drug-eluting stents have been proposed recently as a novel method to potentially reduce restenosis in coronary arteries. A P-32 labeled oligonucleotide (ODN) loaded on a polymer coated stent is slowly released in the arterial wall to deliver a therapeutic dose to the target tissue. However, the relatively low proportion of drugs transferred to the arterial wall (<2%-5% typically) raises questions about the degree to which radiolabeled drugs eluted from the stent can contribute to the total radiation dose delivered to tissues. A three-dimensional diffusion-convection transport model is used to model the transport of a hydrophilic drug released from the surface of a stent to the arterial media. Large drug concentration gradients are observed near the stent struts giving rise to a nonuniform radiation activity distribution for the drug in the tissues as a function of time. A voxel-based kernel convolution method is used to calculate the radiation dose rate resulting from this activity build-up in the arterial wall based on the medical internal radiation dose formalism. Measured residence time for the P-32 ODN in the arterial wall and at the stent surface obtained from animal studies are used to normalize the results in terms of absolute dose to tissue. The results indicate that radiation due to drug eluted from the stent contributes only a small fraction of the total radiation delivered to the arterial wall, the main contribution coming from the activity that remains embedded in the stent coating. For hydrophilic compounds with rapid transit times in arterial tissue and minimal binding interactions, the activity build-up in the arterial wall contributes only a small fraction to the total dose delivered by the P-32 ODN stent. For these compounds, it is concluded that radiolabeled drug-eluting stent will not likely improve the performance of radioactive stents for the treatment of restenosis. Also, variability in the delivery efficacy of drug delivery devices makes accurate dosimetry difficult and the drug washout in the systemic circulatory system may yield an unnecessary activity build-up and dose to healthy organs." @default.
• W2094588193 created "2016-06-24" @default.
• W2094588193 creator A5005687154 @default.
• W2094588193 creator A5005931821 @default.
• W2094588193 creator A5023975576 @default.
• W2094588193 date "2003-09-17" @default.
• W2094588193 modified "2023-10-14" @default.
• W2094588193 title "Dose model for stent-based delivery of a radioactive compound for the treatment of restenosis in coronary arteries" @default.
• W2094588193 cites W1980858075 @default.
• W2094588193 cites W1989919813 @default.
• W2094588193 cites W2008623658 @default.
• W2094588193 cites W2017919038 @default.
• W2094588193 cites W2022081141 @default.
• W2094588193 cites W2084810918 @default.
• W2094588193 cites W2087441280 @default.
• W2094588193 cites W2099494620 @default.
• W2094588193 cites W2101848599 @default.
• W2094588193 cites W2128842001 @default.
• W2094588193 cites W2145340318 @default.
• W2094588193 doi "https://doi.org/10.1118/1.1607506" @default.
• W2094588193 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14596298" @default.
• W2094588193 hasPublicationYear "2003" @default.
• W2094588193 type Work @default.
• W2094588193 sameAs 2094588193 @default.
• W2094588193 citedByCount "8" @default.
• W2094588193 crossrefType "journal-article" @default.
• W2094588193 hasAuthorship W2094588193A5005687154 @default.
• W2094588193 hasAuthorship W2094588193A5005931821 @default.
• W2094588193 hasAuthorship W2094588193A5023975576 @default.
• W2094588193 hasConcept C104293457 @default.
• W2094588193 hasConcept C120665830 @default.
• W2094588193 hasConcept C121332964 @default.
• W2094588193 hasConcept C126838900 @default.
• W2094588193 hasConcept C136229726 @default.
• W2094588193 hasConcept C153385146 @default.
• W2094588193 hasConcept C164705383 @default.
• W2094588193 hasConcept C192562407 @default.
• W2094588193 hasConcept C2776820930 @default.
• W2094588193 hasConcept C2778283817 @default.
• W2094588193 hasConcept C2778583881 @default.
• W2094588193 hasConcept C2778742706 @default.
• W2094588193 hasConcept C2989005 @default.
• W2094588193 hasConcept C3020090656 @default.
• W2094588193 hasConcept C71924100 @default.
• W2094588193 hasConcept C75088862 @default.
• W2094588193 hasConceptScore W2094588193C104293457 @default.
• W2094588193 hasConceptScore W2094588193C120665830 @default.
• W2094588193 hasConceptScore W2094588193C121332964 @default.
• W2094588193 hasConceptScore W2094588193C126838900 @default.
• W2094588193 hasConceptScore W2094588193C136229726 @default.
• W2094588193 hasConceptScore W2094588193C153385146 @default.
• W2094588193 hasConceptScore W2094588193C164705383 @default.
• W2094588193 hasConceptScore W2094588193C192562407 @default.
• W2094588193 hasConceptScore W2094588193C2776820930 @default.
• W2094588193 hasConceptScore W2094588193C2778283817 @default.
• W2094588193 hasConceptScore W2094588193C2778583881 @default.
• W2094588193 hasConceptScore W2094588193C2778742706 @default.
• W2094588193 hasConceptScore W2094588193C2989005 @default.
• W2094588193 hasConceptScore W2094588193C3020090656 @default.
• W2094588193 hasConceptScore W2094588193C71924100 @default.
• W2094588193 hasConceptScore W2094588193C75088862 @default.
• W2094588193 hasIssue "10" @default.
• W2094588193 hasLocation W20945881931 @default.
• W2094588193 hasLocation W20945881932 @default.
• W2094588193 hasOpenAccess W2094588193 @default.
• W2094588193 hasPrimaryLocation W20945881931 @default.
• W2094588193 hasRelatedWork W1180211549 @default.
• W2094588193 hasRelatedWork W1963755174 @default.
• W2094588193 hasRelatedWork W2017903361 @default.
• W2094588193 hasRelatedWork W2030811679 @default.
• W2094588193 hasRelatedWork W2040400039 @default.
• W2094588193 hasRelatedWork W2061442482 @default.
• W2094588193 hasRelatedWork W2113770722 @default.
• W2094588193 hasRelatedWork W2323172316 @default.
• W2094588193 hasRelatedWork W2386428293 @default.
• W2094588193 hasRelatedWork W2593832489 @default.
• W2094588193 hasVolume "30" @default.
• W2094588193 isParatext "false" @default.
• W2094588193 isRetracted "false" @default.
• W2094588193 magId "2094588193" @default.
• W2094588193 workType "article" @default.