Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094597238> ?p ?o ?g. }
- W2094597238 endingPage "67" @default.
- W2094597238 startingPage "53" @default.
- W2094597238 abstract "ABSTRACT Cryptococcosis, caused by the basidiomycetous fungus Cryptococcus neoformans , is responsible for more than 600,000 deaths annually in AIDS patients. Flucytosine is one of the most commonly used antifungal drugs for its treatment, but its resistance and regulatory mechanisms have never been investigated at the genome scale in C. neoformans . In the present study, we performed comparative transcriptome analysis by employing two-component system mutants ( tco1 Δ and tco2 Δ) exhibiting opposing flucytosine susceptibility. As a result, a total of 177 flucytosine-responsive genes were identified, and many of them were found to be regulated by Tco1 or Tco2. Among these, we discovered an APSES-like transcription factor, Mbs1 ( Mb p1- and S wi4-like protein 1). Expression analysis revealed that MBS1 was regulated in response to flucytosine in a Tco2/Hog1-dependent manner. Supporting this, C. neoformans with the deletion of MBS1 exhibited increased susceptibility to flucytosine. Intriguingly, Mbs1 played pleiotropic roles in diverse cellular processes of C. neoformans . Mbs1 positively regulated ergosterol biosynthesis and thereby affected polyene and azole drug susceptibility. Mbs1 was also involved in genotoxic and oxidative stress responses. Furthermore, Mbs1 promoted production of melanin and capsule and thereby was required for full virulence of C. neoformans . In conclusion, Mbs1 is considered to be a novel antifungal therapeutic target for treatment of cryptococcosis." @default.
- W2094597238 created "2016-06-24" @default.
- W2094597238 creator A5012318392 @default.
- W2094597238 creator A5019206595 @default.
- W2094597238 creator A5033845008 @default.
- W2094597238 creator A5034542512 @default.
- W2094597238 creator A5035282230 @default.
- W2094597238 creator A5051546694 @default.
- W2094597238 creator A5052159588 @default.
- W2094597238 creator A5055766451 @default.
- W2094597238 creator A5070751515 @default.
- W2094597238 creator A5076637048 @default.
- W2094597238 creator A5079546347 @default.
- W2094597238 date "2012-01-01" @default.
- W2094597238 modified "2023-10-16" @default.
- W2094597238 title "A Flucytosine-Responsive Mbp1/Swi4-Like Protein, Mbs1, Plays Pleiotropic Roles in Antifungal Drug Resistance, Stress Response, and Virulence of Cryptococcus neoformans" @default.
- W2094597238 cites W1773566318 @default.
- W2094597238 cites W1876617638 @default.
- W2094597238 cites W1982958726 @default.
- W2094597238 cites W1987658252 @default.
- W2094597238 cites W1990111262 @default.
- W2094597238 cites W1992573579 @default.
- W2094597238 cites W1999311978 @default.
- W2094597238 cites W1999340863 @default.
- W2094597238 cites W2000282782 @default.
- W2094597238 cites W2004173797 @default.
- W2094597238 cites W2018094394 @default.
- W2094597238 cites W2018367888 @default.
- W2094597238 cites W2020335235 @default.
- W2094597238 cites W2023722203 @default.
- W2094597238 cites W2026882865 @default.
- W2094597238 cites W2046075462 @default.
- W2094597238 cites W2050630298 @default.
- W2094597238 cites W2055416073 @default.
- W2094597238 cites W2058099105 @default.
- W2094597238 cites W2058216045 @default.
- W2094597238 cites W2079513681 @default.
- W2094597238 cites W2081959052 @default.
- W2094597238 cites W2092686628 @default.
- W2094597238 cites W2093768752 @default.
- W2094597238 cites W2094923559 @default.
- W2094597238 cites W2096155456 @default.
- W2094597238 cites W2098117830 @default.
- W2094597238 cites W2099325822 @default.
- W2094597238 cites W2099573346 @default.
- W2094597238 cites W2104281761 @default.
- W2094597238 cites W2106062461 @default.
- W2094597238 cites W2107277218 @default.
- W2094597238 cites W2108675611 @default.
- W2094597238 cites W2109085633 @default.
- W2094597238 cites W2110382452 @default.
- W2094597238 cites W2112254424 @default.
- W2094597238 cites W2114540804 @default.
- W2094597238 cites W2116627896 @default.
- W2094597238 cites W2121226976 @default.
- W2094597238 cites W2130655869 @default.
- W2094597238 cites W2136651521 @default.
- W2094597238 cites W2137549147 @default.
- W2094597238 cites W2137990078 @default.
- W2094597238 cites W2142544085 @default.
- W2094597238 cites W2145092167 @default.
- W2094597238 cites W2146523084 @default.
- W2094597238 cites W2147478719 @default.
- W2094597238 cites W2150919198 @default.
- W2094597238 cites W2160128383 @default.
- W2094597238 cites W2161004182 @default.
- W2094597238 cites W2162287848 @default.
- W2094597238 cites W2168344348 @default.
- W2094597238 cites W2170598336 @default.
- W2094597238 cites W2323434140 @default.
- W2094597238 cites W4245071100 @default.
- W2094597238 doi "https://doi.org/10.1128/ec.05236-11" @default.
- W2094597238 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3255937" @default.
- W2094597238 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22080454" @default.
- W2094597238 hasPublicationYear "2012" @default.
- W2094597238 type Work @default.
- W2094597238 sameAs 2094597238 @default.
- W2094597238 citedByCount "40" @default.
- W2094597238 countsByYear W20945972382012 @default.
- W2094597238 countsByYear W20945972382013 @default.
- W2094597238 countsByYear W20945972382014 @default.
- W2094597238 countsByYear W20945972382015 @default.
- W2094597238 countsByYear W20945972382016 @default.
- W2094597238 countsByYear W20945972382017 @default.
- W2094597238 countsByYear W20945972382018 @default.
- W2094597238 countsByYear W20945972382019 @default.
- W2094597238 countsByYear W20945972382020 @default.
- W2094597238 countsByYear W20945972382021 @default.
- W2094597238 countsByYear W20945972382022 @default.
- W2094597238 countsByYear W20945972382023 @default.
- W2094597238 crossrefType "journal-article" @default.
- W2094597238 hasAuthorship W2094597238A5012318392 @default.
- W2094597238 hasAuthorship W2094597238A5019206595 @default.
- W2094597238 hasAuthorship W2094597238A5033845008 @default.
- W2094597238 hasAuthorship W2094597238A5034542512 @default.
- W2094597238 hasAuthorship W2094597238A5035282230 @default.
- W2094597238 hasAuthorship W2094597238A5051546694 @default.
- W2094597238 hasAuthorship W2094597238A5052159588 @default.