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• W2094605428 abstract "Abstract: Background: The histological outcome of chronic hepatitis C is better among carriers of the apolipoprotein E (ApoE) ɛ4 allele, for reasons unknown. The orthotopic liver transplantation (OLT) setting allows to separate the role played by liver‐derived ApoE (graft) from ApoE of different origin (recipient). Patients and methods: Forty‐six OLT recipients with recurrent hepatitis C were studied. Grafts and recipients were genotyped for ApoE. In a follow‐up extending up to 4 years, the serum triglycerides‐to‐cholesterol ratio ( T / C ratio) was measured 1 year after OLT, whereas fibrosis progression was assessed yearly and expressed as fibrosis units/month (FU/mo). Results: A T / C ratio ≤0.75 was observed in 13/15 cases in which both donor and recipient were ɛ4 carriers, 10/19 cases in which ɛ4 alleles were of exclusive recipient's origin and 5/12 cases in which ɛ4 alleles were of exclusive donor's origin or absent ( P <0.02). One year after OLT, a fibrosis progression ≤0.100 FU/mo was associated with a low T / C ratio (24/34 vs. 4/12, P <0.05). An Ishak staging score >2 was reached later by male recipients who were ɛ4 carriers ( P <0.002). Conclusions: Recipient's carriage of ApoE ɛ4 affects fibrosis progression of recurrent hepatitis C through gender‐specific mechanisms, associated with a peculiar, ApoE‐associated, lipid profile." @default.
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• W2094605428 date "2005-11-11" @default.
• W2094605428 modified "2023-10-17" @default.
• W2094605428 title "Low fibrosis progression of recurrent hepatitis C in apolipoprotein E e4 carriers: relationship with the blood lipid profile" @default.
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• W2094605428 doi "https://doi.org/10.1111/j.1478-3231.2005.01156.x" @default.
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