FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094607773> ?p ?o ?g. }

• W2094607773 endingPage "2400" @default.
• W2094607773 startingPage "2393" @default.
• W2094607773 abstract "Programmed cell death of granulocytes is one of the mechanisms that limit inflammatory responses. Members of the Bcl-2 protein family are essential regulators of apoptosis induced by growth factor withdrawal or cytotoxic stress. We have used gene-targeted and transgenic mice to investigate the roles of the prosurvival molecules Bcl-2 and Bcl-w and their proapoptotic relatives Bax and Bim in spontaneous and stress-induced apoptosis of granulocytes from bone marrow or the peritoneum. Bim deficiency, like Bcl-2 overexpression, rendered granulocytes resistant to cytokine withdrawal and cytotoxic drugs, but absence of Bax alone had no protective effect. Loss of Bcl-2 or Bcl-w did not increase the sensitivity of granulocytes to any of these apoptotic stimuli, but Bcl-2 was essential for the in vitro survival of myeloid progenitors under conditions of cytokine withdrawal where cell death was mediated, in part, by Bim. Granulocyte colony-stimulating factor (G-CSF), a key survival factor for granulocytes, enhanced viability of cells lacking bcl-2, bcl-w, bax, orbim, indicating that none of these genes alone is the essential target of this cytokine's prosurvival function. Expression analysis of proapoptotic Bcl-2 family members in granulocytes revealed that the BH3-only protein Bmf is induced upon cytokine withdrawal. These results indicate that the BH3-only protein Bim and possibly also Bmf are critical initiators of spontaneous and drug-induced apoptosis of granulocytes, whereas Bcl-2, Bcl-w, and Bax act in a redundant manner in regulating granulocyte survival and death, respectively." @default.
• W2094607773 created "2016-06-24" @default.
• W2094607773 creator A5013658939 @default.
• W2094607773 creator A5046532595 @default.
• W2094607773 creator A5066769237 @default.
• W2094607773 creator A5085126287 @default.
• W2094607773 date "2003-03-15" @default.
• W2094607773 modified "2023-10-14" @default.
• W2094607773 title "Essential role for the BH3-only protein Bim but redundant roles for Bax, Bcl-2, and Bcl-w in the control of granulocyte survival" @default.
• W2094607773 cites W1587890084 @default.
• W2094607773 cites W1822222538 @default.
• W2094607773 cites W189586467 @default.
• W2094607773 cites W1968867081 @default.
• W2094607773 cites W1976968664 @default.
• W2094607773 cites W1981166298 @default.
• W2094607773 cites W1981176905 @default.
• W2094607773 cites W1983310780 @default.
• W2094607773 cites W1983672911 @default.
• W2094607773 cites W199050209 @default.
• W2094607773 cites W1992850462 @default.
• W2094607773 cites W1993059855 @default.
• W2094607773 cites W2008597649 @default.
• W2094607773 cites W2011785467 @default.
• W2094607773 cites W2017628675 @default.
• W2094607773 cites W2026873116 @default.
• W2094607773 cites W2036274324 @default.
• W2094607773 cites W2045211890 @default.
• W2094607773 cites W2059287796 @default.
• W2094607773 cites W2063964334 @default.
• W2094607773 cites W2079650395 @default.
• W2094607773 cites W2088406835 @default.
• W2094607773 cites W2105610538 @default.
• W2094607773 cites W2107528191 @default.
• W2094607773 cites W2116172091 @default.
• W2094607773 cites W2132740145 @default.
• W2094607773 cites W2134622777 @default.
• W2094607773 cites W2137986638 @default.
• W2094607773 cites W2145185496 @default.
• W2094607773 cites W2153987375 @default.
• W2094607773 cites W2157740207 @default.
• W2094607773 cites W2163011434 @default.
• W2094607773 cites W2164753589 @default.
• W2094607773 cites W2166601968 @default.
• W2094607773 cites W2270245312 @default.
• W2094607773 cites W2323400003 @default.
• W2094607773 cites W2398303517 @default.
• W2094607773 cites W2429778852 @default.
• W2094607773 cites W4239718055 @default.
• W2094607773 cites W43460215 @default.
• W2094607773 doi "https://doi.org/10.1182/blood-2002-07-2132" @default.
• W2094607773 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12433687" @default.
• W2094607773 hasPublicationYear "2003" @default.
• W2094607773 type Work @default.
• W2094607773 sameAs 2094607773 @default.
• W2094607773 citedByCount "140" @default.
• W2094607773 countsByYear W20946077732012 @default.
• W2094607773 countsByYear W20946077732013 @default.
• W2094607773 countsByYear W20946077732014 @default.
• W2094607773 countsByYear W20946077732015 @default.
• W2094607773 countsByYear W20946077732016 @default.
• W2094607773 countsByYear W20946077732017 @default.
• W2094607773 countsByYear W20946077732018 @default.
• W2094607773 countsByYear W20946077732019 @default.
• W2094607773 countsByYear W20946077732020 @default.
• W2094607773 countsByYear W20946077732021 @default.
• W2094607773 countsByYear W20946077732022 @default.
• W2094607773 countsByYear W20946077732023 @default.
• W2094607773 crossrefType "journal-article" @default.
• W2094607773 hasAuthorship W2094607773A5013658939 @default.
• W2094607773 hasAuthorship W2094607773A5046532595 @default.
• W2094607773 hasAuthorship W2094607773A5066769237 @default.
• W2094607773 hasAuthorship W2094607773A5085126287 @default.
• W2094607773 hasBestOaLocation W20946077731 @default.
• W2094607773 hasConcept C149150037 @default.
• W2094607773 hasConcept C154317977 @default.
• W2094607773 hasConcept C190283241 @default.
• W2094607773 hasConcept C201750760 @default.
• W2094607773 hasConcept C202751555 @default.
• W2094607773 hasConcept C203014093 @default.
• W2094607773 hasConcept C2776694085 @default.
• W2094607773 hasConcept C2777767877 @default.
• W2094607773 hasConcept C2777983669 @default.
• W2094607773 hasConcept C2778690821 @default.
• W2094607773 hasConcept C2779282312 @default.
• W2094607773 hasConcept C2780007613 @default.
• W2094607773 hasConcept C28328180 @default.
• W2094607773 hasConcept C31573885 @default.
• W2094607773 hasConcept C502942594 @default.
• W2094607773 hasConcept C54355233 @default.
• W2094607773 hasConcept C86803240 @default.
• W2094607773 hasConcept C95444343 @default.
• W2094607773 hasConceptScore W2094607773C149150037 @default.
• W2094607773 hasConceptScore W2094607773C154317977 @default.
• W2094607773 hasConceptScore W2094607773C190283241 @default.
• W2094607773 hasConceptScore W2094607773C201750760 @default.
• W2094607773 hasConceptScore W2094607773C202751555 @default.
• W2094607773 hasConceptScore W2094607773C203014093 @default.
• W2094607773 hasConceptScore W2094607773C2776694085 @default.

• next