Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094609042> ?p ?o ?g. }
- W2094609042 endingPage "894" @default.
- W2094609042 startingPage "889" @default.
- W2094609042 abstract "Previous studies from our laboratory demonstrated that 17beta-estradiol (E2) rapidly inhibits Cl(-) secretion in rat and human distal colonic epithelium. The inhibition has been shown to occur via targeting of a basolateral K(+) channel identified as the KCNQ1 (KvLQT1) channel. E2 indirectly modulates the channel activity via a cascade of second messengers which are rapidly phosphorylated in response to E2. The anti-secretory mechanism may be the manner by which E2 induces fluid retention in the intestine during periods of high circulating plasma E2. Here we review the sex-dependent and estrous cycle regulation of this novel rapid response to E2. The inhibition of KCNQ1 channel activity and Cl(-) secretion will be of interest in the future in the investigation of the retentive effects of estrogen in female tissue and also in the study of secretory disorders and drugable targets of the intestine." @default.
- W2094609042 created "2016-06-24" @default.
- W2094609042 creator A5024709364 @default.
- W2094609042 creator A5041989030 @default.
- W2094609042 date "2008-10-01" @default.
- W2094609042 modified "2023-10-02" @default.
- W2094609042 title "Sex and estrous cycle-dependent rapid protein kinase signaling actions of estrogen in distal colonic cells☆" @default.
- W2094609042 cites W137855893 @default.
- W2094609042 cites W1668163968 @default.
- W2094609042 cites W1795513906 @default.
- W2094609042 cites W1984440203 @default.
- W2094609042 cites W1989542773 @default.
- W2094609042 cites W1999054905 @default.
- W2094609042 cites W2007911517 @default.
- W2094609042 cites W2012892145 @default.
- W2094609042 cites W2013222540 @default.
- W2094609042 cites W2014265593 @default.
- W2094609042 cites W2024732013 @default.
- W2094609042 cites W2027584878 @default.
- W2094609042 cites W2029265861 @default.
- W2094609042 cites W2043074327 @default.
- W2094609042 cites W2051596977 @default.
- W2094609042 cites W2065138547 @default.
- W2094609042 cites W2069938924 @default.
- W2094609042 cites W2070443422 @default.
- W2094609042 cites W2076110449 @default.
- W2094609042 cites W2076821088 @default.
- W2094609042 cites W2085558469 @default.
- W2094609042 cites W2093881154 @default.
- W2094609042 cites W2110918147 @default.
- W2094609042 cites W2112223211 @default.
- W2094609042 cites W2114341652 @default.
- W2094609042 cites W2117856246 @default.
- W2094609042 cites W2126245788 @default.
- W2094609042 cites W2132426879 @default.
- W2094609042 cites W2144603992 @default.
- W2094609042 cites W2148309891 @default.
- W2094609042 cites W2162912541 @default.
- W2094609042 cites W2170372540 @default.
- W2094609042 cites W2180899886 @default.
- W2094609042 cites W2430145915 @default.
- W2094609042 cites W2473744263 @default.
- W2094609042 cites W2479598873 @default.
- W2094609042 cites W41008617 @default.
- W2094609042 doi "https://doi.org/10.1016/j.steroids.2008.01.021" @default.
- W2094609042 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18374379" @default.
- W2094609042 hasPublicationYear "2008" @default.
- W2094609042 type Work @default.
- W2094609042 sameAs 2094609042 @default.
- W2094609042 citedByCount "18" @default.
- W2094609042 countsByYear W20946090422012 @default.
- W2094609042 countsByYear W20946090422013 @default.
- W2094609042 countsByYear W20946090422014 @default.
- W2094609042 countsByYear W20946090422016 @default.
- W2094609042 countsByYear W20946090422017 @default.
- W2094609042 countsByYear W20946090422020 @default.
- W2094609042 countsByYear W20946090422021 @default.
- W2094609042 crossrefType "journal-article" @default.
- W2094609042 hasAuthorship W2094609042A5024709364 @default.
- W2094609042 hasAuthorship W2094609042A5041989030 @default.
- W2094609042 hasConcept C126322002 @default.
- W2094609042 hasConcept C134018914 @default.
- W2094609042 hasConcept C184235292 @default.
- W2094609042 hasConcept C185592680 @default.
- W2094609042 hasConcept C1998276 @default.
- W2094609042 hasConcept C2777164284 @default.
- W2094609042 hasConcept C49039625 @default.
- W2094609042 hasConcept C71315377 @default.
- W2094609042 hasConcept C71924100 @default.
- W2094609042 hasConcept C86803240 @default.
- W2094609042 hasConcept C95444343 @default.
- W2094609042 hasConcept C97029542 @default.
- W2094609042 hasConceptScore W2094609042C126322002 @default.
- W2094609042 hasConceptScore W2094609042C134018914 @default.
- W2094609042 hasConceptScore W2094609042C184235292 @default.
- W2094609042 hasConceptScore W2094609042C185592680 @default.
- W2094609042 hasConceptScore W2094609042C1998276 @default.
- W2094609042 hasConceptScore W2094609042C2777164284 @default.
- W2094609042 hasConceptScore W2094609042C49039625 @default.
- W2094609042 hasConceptScore W2094609042C71315377 @default.
- W2094609042 hasConceptScore W2094609042C71924100 @default.
- W2094609042 hasConceptScore W2094609042C86803240 @default.
- W2094609042 hasConceptScore W2094609042C95444343 @default.
- W2094609042 hasConceptScore W2094609042C97029542 @default.
- W2094609042 hasIssue "9-10" @default.
- W2094609042 hasLocation W20946090421 @default.
- W2094609042 hasLocation W20946090422 @default.
- W2094609042 hasOpenAccess W2094609042 @default.
- W2094609042 hasPrimaryLocation W20946090421 @default.
- W2094609042 hasRelatedWork W1966283443 @default.
- W2094609042 hasRelatedWork W1977698842 @default.
- W2094609042 hasRelatedWork W2000124881 @default.
- W2094609042 hasRelatedWork W2013275608 @default.
- W2094609042 hasRelatedWork W2014570372 @default.
- W2094609042 hasRelatedWork W2036659686 @default.
- W2094609042 hasRelatedWork W2057217014 @default.
- W2094609042 hasRelatedWork W2081351255 @default.
- W2094609042 hasRelatedWork W2101390122 @default.