FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094624555> ?p ?o ?g. }

• W2094624555 endingPage "564" @default.
• W2094624555 startingPage "558" @default.
• W2094624555 abstract "Smoking is a significant independent risk factor for cardiovascular disease. Among the chemicals present in the cigarette smoke, nicotine is responsible for much of the damage; it induces marked vessel morphological dysfunction and vasoconstriction. Unfortunately, pharmacological or behavioural treatment is not useful against cigarette smoking. The purpose of this study is to test, in experimental conditions, the therapeutic ability of exogenous melatonin administered after smoking-induced vasculopathy and to evaluate the targets of its effects. Nicotine was orally administered for 28 days. Thereafter, the rats were orally treated with melatonin for another 28 days. Vessel damage, an important vasoconstrictor peptide (endothelin-1) and the oxidative stress markers were analysed. Nicotine treatment induced marked endothelial damage and an obvious vasoconstriction in the aorta as evaluated by an increased endothelin-1 (ET-1) expression. These alterations were correlated with a reduction of endothelial nitric oxide synthase (eNOS) and superoxide dismutase (SOD) and with increases of heat shock protein (Hsp70) and inducible nitric oxide synthase (iNOS) activities. Melatonin not only improved the impairment of endothelial-dependent relaxation, but also induced the increase of eNOS and SOD and the reduction of iNOS and Hsp70. The findings indicate that nicotine is associated with an elevated synthesis of the vasoconstrictor peptide (ET-1); it also induces a reduction of nitric oxide-mediated vasodilatation (eNOS) and promotes oxidative stress in the vessel wall. We propose that melatonin should be considered as a therapeutic intervention for smokers since it reduces vasoconstriction and oxidative stress and improves endothelial physiology." @default.
• W2094624555 created "2016-06-24" @default.
• W2094624555 creator A5007772278 @default.
• W2094624555 creator A5042471736 @default.
• W2094624555 creator A5063159500 @default.
• W2094624555 creator A5075965492 @default.
• W2094624555 creator A5076515437 @default.
• W2094624555 date "2010-10-01" @default.
• W2094624555 modified "2023-10-18" @default.
• W2094624555 title "Endothelin-1 as a potential marker of melatonin's therapeutic effects in smoking-induced vasculopathy" @default.
• W2094624555 cites W1511296430 @default.
• W2094624555 cites W1903574773 @default.
• W2094624555 cites W1967767433 @default.
• W2094624555 cites W1972748028 @default.
• W2094624555 cites W1972951963 @default.
• W2094624555 cites W1973759965 @default.
• W2094624555 cites W1988934115 @default.
• W2094624555 cites W1995384087 @default.
• W2094624555 cites W2003995353 @default.
• W2094624555 cites W2005931041 @default.
• W2094624555 cites W2007129713 @default.
• W2094624555 cites W2007394108 @default.
• W2094624555 cites W2020951058 @default.
• W2094624555 cites W2024282534 @default.
• W2094624555 cites W2029588101 @default.
• W2094624555 cites W2030318393 @default.
• W2094624555 cites W2039425156 @default.
• W2094624555 cites W2046830075 @default.
• W2094624555 cites W2047742688 @default.
• W2094624555 cites W2068139562 @default.
• W2094624555 cites W2069866574 @default.
• W2094624555 cites W2092624181 @default.
• W2094624555 cites W2102372635 @default.
• W2094624555 cites W2105541876 @default.
• W2094624555 cites W2106310898 @default.
• W2094624555 cites W2109198113 @default.
• W2094624555 cites W2135330383 @default.
• W2094624555 cites W2163067055 @default.
• W2094624555 cites W2312882033 @default.
• W2094624555 cites W779421447 @default.
• W2094624555 doi "https://doi.org/10.1016/j.lfs.2010.09.011" @default.
• W2094624555 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20854829" @default.
• W2094624555 hasPublicationYear "2010" @default.
• W2094624555 type Work @default.
• W2094624555 sameAs 2094624555 @default.
• W2094624555 citedByCount "33" @default.
• W2094624555 countsByYear W20946245552012 @default.
• W2094624555 countsByYear W20946245552013 @default.
• W2094624555 countsByYear W20946245552014 @default.
• W2094624555 countsByYear W20946245552016 @default.
• W2094624555 countsByYear W20946245552017 @default.
• W2094624555 countsByYear W20946245552018 @default.
• W2094624555 countsByYear W20946245552019 @default.
• W2094624555 countsByYear W20946245552020 @default.
• W2094624555 countsByYear W20946245552021 @default.
• W2094624555 countsByYear W20946245552022 @default.
• W2094624555 countsByYear W20946245552023 @default.
• W2094624555 crossrefType "journal-article" @default.
• W2094624555 hasAuthorship W2094624555A5007772278 @default.
• W2094624555 hasAuthorship W2094624555A5042471736 @default.
• W2094624555 hasAuthorship W2094624555A5063159500 @default.
• W2094624555 hasAuthorship W2094624555A5075965492 @default.
• W2094624555 hasAuthorship W2094624555A5076515437 @default.
• W2094624555 hasConcept C120770815 @default.
• W2094624555 hasConcept C126322002 @default.
• W2094624555 hasConcept C134018914 @default.
• W2094624555 hasConcept C144980905 @default.
• W2094624555 hasConcept C149601957 @default.
• W2094624555 hasConcept C170493617 @default.
• W2094624555 hasConcept C185592680 @default.
• W2094624555 hasConcept C2775838275 @default.
• W2094624555 hasConcept C2776151105 @default.
• W2094624555 hasConcept C2777622882 @default.
• W2094624555 hasConcept C2778182776 @default.
• W2094624555 hasConcept C2778326061 @default.
• W2094624555 hasConcept C2779547902 @default.
• W2094624555 hasConcept C2779961880 @default.
• W2094624555 hasConcept C2780972559 @default.
• W2094624555 hasConcept C519581460 @default.
• W2094624555 hasConcept C71924100 @default.
• W2094624555 hasConcept C98274493 @default.
• W2094624555 hasConceptScore W2094624555C120770815 @default.
• W2094624555 hasConceptScore W2094624555C126322002 @default.
• W2094624555 hasConceptScore W2094624555C134018914 @default.
• W2094624555 hasConceptScore W2094624555C144980905 @default.
• W2094624555 hasConceptScore W2094624555C149601957 @default.
• W2094624555 hasConceptScore W2094624555C170493617 @default.
• W2094624555 hasConceptScore W2094624555C185592680 @default.
• W2094624555 hasConceptScore W2094624555C2775838275 @default.
• W2094624555 hasConceptScore W2094624555C2776151105 @default.
• W2094624555 hasConceptScore W2094624555C2777622882 @default.
• W2094624555 hasConceptScore W2094624555C2778182776 @default.
• W2094624555 hasConceptScore W2094624555C2778326061 @default.
• W2094624555 hasConceptScore W2094624555C2779547902 @default.
• W2094624555 hasConceptScore W2094624555C2779961880 @default.
• W2094624555 hasConceptScore W2094624555C2780972559 @default.
• W2094624555 hasConceptScore W2094624555C519581460 @default.
• W2094624555 hasConceptScore W2094624555C71924100 @default.

• next