FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094626757> ?p ?o ?g. }

• W2094626757 endingPage "246" @default.
• W2094626757 startingPage "237" @default.
• W2094626757 abstract "The urokinase-type plasminogen activator (uPA) system is a dynamic complex in which the membrane receptor uPAR binds uPA that binds the plasminogen activator inhibitor (PAI)-1 localized in the extracellular matrix, resulting in endocytosis of the whole complex by the low-density lipoprotein receptor-related protein (LRP). High expression of PAI-1 is paradoxically associated with marked tumor spreading and poor prognosis. We previously reported a nonproteolytic role of the [uPAR:uPA:PAI-1:LRP] complex operative in cell migration. Here we explored whether matrix PAI-1 could be used as a migration support by human breast cancer cells. We showed that the uPA system and LRP are localized at filopodia of invasive cells, and that formation/internalization of the [uPAR:uPA:PAI-1:LRP] complex is required for attachment and migration of cancer cells on plastic and on a PAI-1 coat. PAI-1 increased both filopodia formation and migration of cancer cells suggesting a chemokine-like activity. Migration velocity, expression of the uPA system, use of the [uPAR:uPA:PAI-1:LRP] complex to migrate, and promigratory effects of PAI-1 paralleled cancer cell invasiveness. Phenotyping and functional analysis of invasive cancer cell subclones indicated that different cell subpopulations may use different strategies to migrate depending on both the environment and their expression of the uPA system, some of them taking advantage of abundant available PAI-1." @default.
• W2094626757 created "2016-06-24" @default.
• W2094626757 creator A5034811801 @default.
• W2094626757 creator A5041161864 @default.
• W2094626757 creator A5044844745 @default.
• W2094626757 creator A5046657581 @default.
• W2094626757 creator A5057631651 @default.
• W2094626757 creator A5080020209 @default.
• W2094626757 date "2002-01-01" @default.
• W2094626757 modified "2023-10-08" @default.
• W2094626757 title "Promigratory Effect of Plasminogen Activator Inhibitor-1 on Invasive Breast Cancer Cell Populations" @default.
• W2094626757 cites W100835554 @default.
• W2094626757 cites W1485224770 @default.
• W2094626757 cites W1491650478 @default.
• W2094626757 cites W1502897331 @default.
• W2094626757 cites W1574621194 @default.
• W2094626757 cites W1583346750 @default.
• W2094626757 cites W1601891991 @default.
• W2094626757 cites W1703472112 @default.
• W2094626757 cites W1926488772 @default.
• W2094626757 cites W1964167263 @default.
• W2094626757 cites W1967265143 @default.
• W2094626757 cites W1970314658 @default.
• W2094626757 cites W1972671863 @default.
• W2094626757 cites W1978206983 @default.
• W2094626757 cites W1988650452 @default.
• W2094626757 cites W1990303944 @default.
• W2094626757 cites W1991070447 @default.
• W2094626757 cites W1996165246 @default.
• W2094626757 cites W1997012892 @default.
• W2094626757 cites W1999684167 @default.
• W2094626757 cites W2002387352 @default.
• W2094626757 cites W2003593894 @default.
• W2094626757 cites W2005113904 @default.
• W2094626757 cites W2013336992 @default.
• W2094626757 cites W2014069639 @default.
• W2094626757 cites W2026800576 @default.
• W2094626757 cites W2028798638 @default.
• W2094626757 cites W2032275066 @default.
• W2094626757 cites W2043090087 @default.
• W2094626757 cites W2049032687 @default.
• W2094626757 cites W2051300009 @default.
• W2094626757 cites W2056432376 @default.
• W2094626757 cites W2069353852 @default.
• W2094626757 cites W2078142004 @default.
• W2094626757 cites W2079607432 @default.
• W2094626757 cites W2079833251 @default.
• W2094626757 cites W2084330742 @default.
• W2094626757 cites W2085929514 @default.
• W2094626757 cites W2086243507 @default.
• W2094626757 cites W2102577298 @default.
• W2094626757 cites W2113370863 @default.
• W2094626757 cites W2121799544 @default.
• W2094626757 cites W2127611014 @default.
• W2094626757 cites W2128647783 @default.
• W2094626757 cites W2129938127 @default.
• W2094626757 cites W2145393717 @default.
• W2094626757 cites W2147425697 @default.
• W2094626757 cites W2154671319 @default.
• W2094626757 cites W2164921896 @default.
• W2094626757 cites W2214504257 @default.
• W2094626757 cites W2255395527 @default.
• W2094626757 cites W2397045198 @default.
• W2094626757 cites W2404535985 @default.
• W2094626757 cites W2408825877 @default.
• W2094626757 cites W4243241283 @default.
• W2094626757 doi "https://doi.org/10.1016/s0002-9440(10)64367-2" @default.
• W2094626757 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1867133" @default.
• W2094626757 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11786417" @default.
• W2094626757 hasPublicationYear "2002" @default.
• W2094626757 type Work @default.
• W2094626757 sameAs 2094626757 @default.
• W2094626757 citedByCount "102" @default.
• W2094626757 countsByYear W20946267572012 @default.
• W2094626757 countsByYear W20946267572013 @default.
• W2094626757 countsByYear W20946267572014 @default.
• W2094626757 countsByYear W20946267572015 @default.
• W2094626757 countsByYear W20946267572017 @default.
• W2094626757 countsByYear W20946267572018 @default.
• W2094626757 countsByYear W20946267572020 @default.
• W2094626757 countsByYear W20946267572021 @default.
• W2094626757 countsByYear W20946267572022 @default.
• W2094626757 countsByYear W20946267572023 @default.
• W2094626757 crossrefType "journal-article" @default.
• W2094626757 hasAuthorship W2094626757A5034811801 @default.
• W2094626757 hasAuthorship W2094626757A5041161864 @default.
• W2094626757 hasAuthorship W2094626757A5044844745 @default.
• W2094626757 hasAuthorship W2094626757A5046657581 @default.
• W2094626757 hasAuthorship W2094626757A5057631651 @default.
• W2094626757 hasAuthorship W2094626757A5080020209 @default.
• W2094626757 hasBestOaLocation W20946267572 @default.
• W2094626757 hasConcept C121608353 @default.
• W2094626757 hasConcept C125705527 @default.
• W2094626757 hasConcept C134018914 @default.
• W2094626757 hasConcept C137738243 @default.
• W2094626757 hasConcept C139770010 @default.
• W2094626757 hasConcept C1491633281 @default.
• W2094626757 hasConcept C189165786 @default.

• next