Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094630005> ?p ?o ?g. }
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- W2094630005 abstract "Bone metastatic disease is a late-stage event of many common cancers, such as those of prostate and breast. It is incurable and causes severe morbidity. Tumor and bone interact in a vicious cycle, where tumor-secreted factors stimulate bone cells, which in turn release growth factors and cytokines that act back on the tumor cells. Within the vicious cycle are many potential therapeutic targets for novel treatment of bone metastatic disease. Therapeutic strategies can be oriented to inhibit bone cells (osteoclasts and osteoblasts) or tumor responses to factors enriched in the bone microenvironment. Many publications, especially from pre-clinical animal models, show that this approach, especially combination treatments, can reduce tumor burden and tumor-derived bone lesions. This supports a novel paradigm: tumor growth can be effectively inhibited by targeting the bone and its microenvironment rather than the tumor itself alone." @default.
- W2094630005 created "2016-06-24" @default.
- W2094630005 creator A5003565243 @default.
- W2094630005 creator A5051232543 @default.
- W2094630005 creator A5067966389 @default.
- W2094630005 date "2009-10-01" @default.
- W2094630005 modified "2023-10-16" @default.
- W2094630005 title "The critical role of the bone microenvironment in cancer metastases" @default.
- W2094630005 cites W1573798987 @default.
- W2094630005 cites W1917534569 @default.
- W2094630005 cites W1965734230 @default.
- W2094630005 cites W1973711833 @default.
- W2094630005 cites W1974444359 @default.
- W2094630005 cites W1975522291 @default.
- W2094630005 cites W1976958448 @default.
- W2094630005 cites W1982915376 @default.
- W2094630005 cites W1984406654 @default.
- W2094630005 cites W1985143543 @default.
- W2094630005 cites W1986471913 @default.
- W2094630005 cites W1987115986 @default.
- W2094630005 cites W1987439849 @default.
- W2094630005 cites W1989526399 @default.
- W2094630005 cites W1993016627 @default.
- W2094630005 cites W1995975385 @default.
- W2094630005 cites W1996946402 @default.
- W2094630005 cites W1998324511 @default.
- W2094630005 cites W2002084575 @default.
- W2094630005 cites W2003404796 @default.
- W2094630005 cites W2003657739 @default.
- W2094630005 cites W2004015317 @default.
- W2094630005 cites W2004337395 @default.
- W2094630005 cites W2011218754 @default.
- W2094630005 cites W2012313734 @default.
- W2094630005 cites W2017209924 @default.
- W2094630005 cites W2017456279 @default.
- W2094630005 cites W2018657706 @default.
- W2094630005 cites W2018806950 @default.
- W2094630005 cites W2018901544 @default.
- W2094630005 cites W2019033245 @default.
- W2094630005 cites W2023659903 @default.
- W2094630005 cites W2025322413 @default.
- W2094630005 cites W2027525928 @default.
- W2094630005 cites W2029728509 @default.
- W2094630005 cites W2032506765 @default.
- W2094630005 cites W2042985720 @default.
- W2094630005 cites W2043536378 @default.
- W2094630005 cites W2047253593 @default.
- W2094630005 cites W2051528631 @default.
- W2094630005 cites W2054121301 @default.
- W2094630005 cites W2055984940 @default.
- W2094630005 cites W2063076489 @default.
- W2094630005 cites W2065771840 @default.
- W2094630005 cites W2067609789 @default.
- W2094630005 cites W2068627477 @default.
- W2094630005 cites W2069074338 @default.
- W2094630005 cites W2074018758 @default.
- W2094630005 cites W2076220903 @default.
- W2094630005 cites W2076335691 @default.
- W2094630005 cites W2077098300 @default.
- W2094630005 cites W2077123765 @default.
- W2094630005 cites W2077342518 @default.
- W2094630005 cites W2078985610 @default.
- W2094630005 cites W2083337630 @default.
- W2094630005 cites W2085960871 @default.
- W2094630005 cites W2086364694 @default.
- W2094630005 cites W2087200744 @default.
- W2094630005 cites W2090589680 @default.
- W2094630005 cites W2090863165 @default.
- W2094630005 cites W2096980599 @default.
- W2094630005 cites W2102352213 @default.
- W2094630005 cites W2102392020 @default.
- W2094630005 cites W2102884576 @default.
- W2094630005 cites W2103904089 @default.
- W2094630005 cites W2108706718 @default.
- W2094630005 cites W2109615647 @default.
- W2094630005 cites W2111807012 @default.
- W2094630005 cites W2112523271 @default.
- W2094630005 cites W2113500634 @default.
- W2094630005 cites W2113503879 @default.
- W2094630005 cites W2116403488 @default.
- W2094630005 cites W2123640548 @default.
- W2094630005 cites W2124281312 @default.
- W2094630005 cites W2145269260 @default.
- W2094630005 cites W2146278165 @default.
- W2094630005 cites W2147754310 @default.
- W2094630005 cites W2149433387 @default.
- W2094630005 cites W2150569195 @default.
- W2094630005 cites W2156920440 @default.
- W2094630005 cites W2156938611 @default.
- W2094630005 cites W2158481098 @default.
- W2094630005 cites W2159590253 @default.
- W2094630005 cites W2162002092 @default.
- W2094630005 cites W2163048481 @default.
- W2094630005 cites W2163276338 @default.
- W2094630005 cites W2165726895 @default.
- W2094630005 cites W2166303017 @default.
- W2094630005 cites W2167775400 @default.
- W2094630005 cites W2338225958 @default.