FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094639672> ?p ?o ?g. }

• W2094639672 endingPage "180" @default.
• W2094639672 startingPage "175" @default.
• W2094639672 abstract "It is well established that the isolated chick pineal gland is directly light sensitive and that melatonin synthesis of the gland can be inhibited by exposing the gland to light during scotophase. Since not all the steps of the phototransduction cascade have been clarified to the same extent as in the retina, we have treated isolated chick pineal glands with 90 min of light during scotophase and with drugs that affect key-components of vertebrate phototransduction, i.e., cyclic guanosine monophosphate (cGMP) phosphodiesterase 6 (PDE6), cGMP levels and cGMP-gated calcium channels. The endpoint measured was the activity of the rate-limiting enzyme of melatonin synthesis, arylalkylamine N-acetyltransferase (AA-NAT), which is inhibited by light. The effects on AA-NAT activity of light were negated by addition of dipyridamol and zaprinast, either of which inhibits the light-induced activation of PDE6. The effect of light was also counteracted by the nitric oxide donor sodium nitroprusside and C-type natriuretic peptide, both of which increase cGMP levels, and by the calcium channel agonist Bay K 8644, which prevents the cGMP-decrease-induced closure of cGMP-gated calcium channels. Inhibition of nitric oxide synthase (NOS) by N(G)-nitro-l-arginine did not influence the inhibitory effect of light, suggesting that the NOS pathway does not play a role. Since the light effect on AA-NAT activity involves both cGMP and cyclic adenosine monophosphate (cAMP) hydrolysis, we have also studied whether the cGMP-inhibited cAMP phosphodiesterase 3 (PDE3) is involved. As the specific PDE3 inhibitor cilostamide is without effect, we assume that the light-induced decrease of cAMP levels does not involve PDE3. These results taken together strongly suggest that the investigated steps of the phototransduction cascade in the isolated chick pineal gland are basically similar to those in the retina." @default.
• W2094639672 created "2016-06-24" @default.
• W2094639672 creator A5001295418 @default.
• W2094639672 creator A5077998018 @default.
• W2094639672 date "2004-03-01" @default.
• W2094639672 modified "2023-10-16" @default.
• W2094639672 title "The phototransduction cascade in the isolated chick pineal gland revisited" @default.
• W2094639672 cites W1566667083 @default.
• W2094639672 cites W1595517259 @default.
• W2094639672 cites W1668745163 @default.
• W2094639672 cites W1983932491 @default.
• W2094639672 cites W1985783829 @default.
• W2094639672 cites W1987654762 @default.
• W2094639672 cites W1990895562 @default.
• W2094639672 cites W1994574383 @default.
• W2094639672 cites W1994751177 @default.
• W2094639672 cites W1999169336 @default.
• W2094639672 cites W2006697935 @default.
• W2094639672 cites W2007897296 @default.
• W2094639672 cites W2009082256 @default.
• W2094639672 cites W2011881251 @default.
• W2094639672 cites W2017771024 @default.
• W2094639672 cites W2026285602 @default.
• W2094639672 cites W2029852974 @default.
• W2094639672 cites W2052079679 @default.
• W2094639672 cites W2053780840 @default.
• W2094639672 cites W2066022164 @default.
• W2094639672 cites W2066592246 @default.
• W2094639672 cites W2066857634 @default.
• W2094639672 cites W2067641362 @default.
• W2094639672 cites W2068077032 @default.
• W2094639672 cites W2070429490 @default.
• W2094639672 cites W2071250685 @default.
• W2094639672 cites W2071633357 @default.
• W2094639672 cites W2071915650 @default.
• W2094639672 cites W2073359096 @default.
• W2094639672 cites W2076339163 @default.
• W2094639672 cites W2077628548 @default.
• W2094639672 cites W2078895135 @default.
• W2094639672 cites W2080696396 @default.
• W2094639672 cites W2094253653 @default.
• W2094639672 cites W2109552214 @default.
• W2094639672 cites W2146085953 @default.
• W2094639672 cites W2167545713 @default.
• W2094639672 cites W4245694795 @default.
• W2094639672 doi "https://doi.org/10.1016/j.brainres.2003.11.059" @default.
• W2094639672 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14759496" @default.
• W2094639672 hasPublicationYear "2004" @default.
• W2094639672 type Work @default.
• W2094639672 sameAs 2094639672 @default.
• W2094639672 citedByCount "16" @default.
• W2094639672 countsByYear W20946396722013 @default.
• W2094639672 countsByYear W20946396722014 @default.
• W2094639672 countsByYear W20946396722020 @default.
• W2094639672 countsByYear W20946396722021 @default.
• W2094639672 countsByYear W20946396722022 @default.
• W2094639672 crossrefType "journal-article" @default.
• W2094639672 hasAuthorship W2094639672A5001295418 @default.
• W2094639672 hasAuthorship W2094639672A5077998018 @default.
• W2094639672 hasConcept C126322002 @default.
• W2094639672 hasConcept C131667965 @default.
• W2094639672 hasConcept C134018914 @default.
• W2094639672 hasConcept C181199279 @default.
• W2094639672 hasConcept C185592680 @default.
• W2094639672 hasConcept C18699975 @default.
• W2094639672 hasConcept C202023056 @default.
• W2094639672 hasConcept C24998067 @default.
• W2094639672 hasConcept C2776846068 @default.
• W2094639672 hasConcept C2778182776 @default.
• W2094639672 hasConcept C2779276759 @default.
• W2094639672 hasConcept C2779610285 @default.
• W2094639672 hasConcept C2780059843 @default.
• W2094639672 hasConcept C2780827179 @default.
• W2094639672 hasConcept C2780994212 @default.
• W2094639672 hasConcept C2781298581 @default.
• W2094639672 hasConcept C3020139451 @default.
• W2094639672 hasConcept C519063684 @default.
• W2094639672 hasConcept C519581460 @default.
• W2094639672 hasConcept C55493867 @default.
• W2094639672 hasConcept C58141971 @default.
• W2094639672 hasConcept C62826618 @default.
• W2094639672 hasConcept C71924100 @default.
• W2094639672 hasConcept C79418042 @default.
• W2094639672 hasConcept C86803240 @default.
• W2094639672 hasConceptScore W2094639672C126322002 @default.
• W2094639672 hasConceptScore W2094639672C131667965 @default.
• W2094639672 hasConceptScore W2094639672C134018914 @default.
• W2094639672 hasConceptScore W2094639672C181199279 @default.
• W2094639672 hasConceptScore W2094639672C185592680 @default.
• W2094639672 hasConceptScore W2094639672C18699975 @default.
• W2094639672 hasConceptScore W2094639672C202023056 @default.
• W2094639672 hasConceptScore W2094639672C24998067 @default.
• W2094639672 hasConceptScore W2094639672C2776846068 @default.
• W2094639672 hasConceptScore W2094639672C2778182776 @default.
• W2094639672 hasConceptScore W2094639672C2779276759 @default.
• W2094639672 hasConceptScore W2094639672C2779610285 @default.
• W2094639672 hasConceptScore W2094639672C2780059843 @default.
• W2094639672 hasConceptScore W2094639672C2780827179 @default.

• next