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- W2094646968 abstract "Antigen (Ag)-specific CD8+ T-cell responses exhibit remarkably similar kinetics after different types of infection. Starting from levels that are virtually undetectable in vivo, pathogen-specific naïve CD8+ T cells are precisely regulated to go through rapid expansion and contraction (death) phases, achieving memory levels of Ag-specific CD8+ T cells that are maintained for the life of the host. However, the exact mechanisms used to achieve appropriate and reproducible CD8+ T-cell homeostasis in response to diverse pathogens remain to be determined. The possibility that early events after infection regulate major features of Ag-specific CD8+ T-cell homeostasis will be discussed here." @default.
- W2094646968 created "2016-06-24" @default.
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- W2094646968 date "2002-04-01" @default.
- W2094646968 modified "2023-10-18" @default.
- W2094646968 title "CD8+ T-cell homeostasis after infection: setting the ‘curve’" @default.
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- W2094646968 doi "https://doi.org/10.1016/s1286-4579(02)01558-7" @default.
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