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• W2094654487 abstract "In a recent phase I study, a combination of gemcitabine at 10 mg/(m2 min) for 12 h and mitoxantrone 12 mg/m2 daily for 3 days, achieved a complete remission (CR) in 3 of 12 (25%) patients with refractory leukemia. A pilot assessment of this regimen was conducted to determine its tolerability in patients with refractory acute myeloid leukemia (AML). In a cohort of 18 patients with very refractory disease (6 primary refractory, 12 relapsed, mean initial CR duration 3.5 months), one patient achieved a CR, a second CR with incomplete platelet recovery (CRp). Sepsis and mucositis were significant extramedullary toxicities. The gemcitabine and mitoxantrone regimen was feasible to administer even in heavily pre-treated patients. It was not active in patients who had failed a prior salvage regimen. It may warrant further study in patients with primary resistant AML." @default.
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• W2094654487 date "2003-04-01" @default.
• W2094654487 modified "2023-10-15" @default.
• W2094654487 title "Mitoxantrone and prolonged infusion gemcitabine as salvage therapy in patients with acute myelogenous leukemia" @default.
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• W2094654487 doi "https://doi.org/10.1016/s0145-2126(02)00171-6" @default.
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