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- W2094657130 abstract "The oximes, pyridine-2-aldoxime (2-PAM) and diacetyl monoxime (DAM), protected against the inhibition of human cholinesterase enzymes by organophosphorus and quaternary ammonium anticholinesterase compounds in vitro, and 2-PAM reversed this inhibition. The oximes reversed neuromuscular block and plasma and red blood cell cholinesterase inhibition produced in normal subjects by the administration of sarin, neostigmine, bis-neostigmine, pyridostigmine, bis-pyridostigmine and ambenomium. The intravenous dose required to alleviate generalized weakness was 1,000 to 2,000 mg. These doses did not relieve the muscarine-like effects of the anticholinesterase compounds, and their influence on central neural effects was not pronounced. DAM produced local burning and mild systemic symptoms. 2-PAM produced a transient, local neuromuscular block following the intra-arterial injection of high concentrations. This was enhanced by the prior injection of anticholinesterase compound. 2-PAM and DAM are valuable adjuncts to atropine in the management of anticholinesterase intoxication, and should diminish the necessity for, or duration of, artificial respiration and endotracheal intubation." @default.
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- W2094657130 date "1958-04-01" @default.
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- W2094657130 title "Use of oximes in the treatment of intoxication by anticholinesterase compounds in normal subjects" @default.
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- W2094657130 doi "https://doi.org/10.1016/0002-9343(58)90290-0" @default.
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