FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094658637> ?p ?o ?g. }

• W2094658637 abstract "Even though a wide range of anticancer agents have been developed, many patients with advanced solid tumors still have a poor prognosis. For the treatment of advanced lung cancer, there are many anticancer agents in clinical use, such as cisplatin, carboplatin, docetaxel, paclitaxel, vinorelbine, gemicitabine, fluorouracil (5FU) derivatives, and irinotecan. A number of combination therapy regimens employing platinum compounds have proven to be effective and are widely applied for the initial treatment of inoperative non-small cell lung cancer (NSCLC). In addition, docetaxel, pemetrexed, and epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors have been reported to be effective in the context of second-line chemotherapy for NSCLC. However, the effect of these therapies on improving patient survival remains far from satisfactory. It is consequently desirable to find more appropriate therapeutic opportunities for NSCLC. Recently, molecularly targeted therapy for cancer has made substantial progress. Histone deacetylase (HDAC) inhibitors have been shown to acetylate the nucleosomal histones of condensed chromatin, and cause the reactivation of genes silenced by hyperacetylating histones. HDAC inhibitors, including suberoylanilide hydroxamic acid (SAHA), have demonstrated therapeutic benefits as monotherapy in hematologic, breast, and bladder malignancies, as well as mesothelioma and NSCLC, without evidence of severe adverse events. Recently, it has been demonstrated that combinations of HDAC inhibitors with well-established chemotherapeutic agents have synergistic antitumor effects via the modulation of biomarkers by HDAC inhibitors. We clarified the predictive markers to select patients receiving this treatment and found a new strategy against lung cancer by using the anticancer drug fluorouracil." @default.
• W2094658637 created "2016-06-24" @default.
• W2094658637 creator A5001124321 @default.
• W2094658637 creator A5011533142 @default.
• W2094658637 creator A5023890444 @default.
• W2094658637 creator A5027883206 @default.
• W2094658637 creator A5037262012 @default.
• W2094658637 creator A5048704135 @default.
• W2094658637 creator A5054938771 @default.
• W2094658637 creator A5064714542 @default.
• W2094658637 creator A5065516346 @default.
• W2094658637 creator A5069126183 @default.
• W2094658637 creator A5076318118 @default.
• W2094658637 creator A5083733013 @default.
• W2094658637 creator A5087922163 @default.
• W2094658637 date "2009-01-01" @default.
• W2094658637 modified "2023-09-26" @default.
• W2094658637 title "The Anticancer Effect of Histone Deacetylase Inhibitors and Combination with the Cytotoxic Agents in Lung Cancer Cells: Biological Analyses for Future Clinical Application" @default.
• W2094658637 doi "https://doi.org/10.1272/jnms.76.44" @default.
• W2094658637 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19305113" @default.
• W2094658637 hasPublicationYear "2009" @default.
• W2094658637 type Work @default.
• W2094658637 sameAs 2094658637 @default.
• W2094658637 citedByCount "2" @default.
• W2094658637 countsByYear W20946586372013 @default.
• W2094658637 countsByYear W20946586372016 @default.
• W2094658637 crossrefType "journal-article" @default.
• W2094658637 hasAuthorship W2094658637A5001124321 @default.
• W2094658637 hasAuthorship W2094658637A5011533142 @default.
• W2094658637 hasAuthorship W2094658637A5023890444 @default.
• W2094658637 hasAuthorship W2094658637A5027883206 @default.
• W2094658637 hasAuthorship W2094658637A5037262012 @default.
• W2094658637 hasAuthorship W2094658637A5048704135 @default.
• W2094658637 hasAuthorship W2094658637A5054938771 @default.
• W2094658637 hasAuthorship W2094658637A5064714542 @default.
• W2094658637 hasAuthorship W2094658637A5065516346 @default.
• W2094658637 hasAuthorship W2094658637A5069126183 @default.
• W2094658637 hasAuthorship W2094658637A5076318118 @default.
• W2094658637 hasAuthorship W2094658637A5083733013 @default.
• W2094658637 hasAuthorship W2094658637A5087922163 @default.
• W2094658637 hasBestOaLocation W20946586371 @default.
• W2094658637 hasConcept C104317684 @default.
• W2094658637 hasConcept C121608353 @default.
• W2094658637 hasConcept C126322002 @default.
• W2094658637 hasConcept C143998085 @default.
• W2094658637 hasConcept C2776256026 @default.
• W2094658637 hasConcept C2776694085 @default.
• W2094658637 hasConcept C2776999253 @default.
• W2094658637 hasConcept C2777240266 @default.
• W2094658637 hasConcept C2777292972 @default.
• W2094658637 hasConcept C2778239845 @default.
• W2094658637 hasConcept C2778305200 @default.
• W2094658637 hasConcept C2780259306 @default.
• W2094658637 hasConcept C2780350996 @default.
• W2094658637 hasConcept C2781190966 @default.
• W2094658637 hasConcept C2781451048 @default.
• W2094658637 hasConcept C502942594 @default.
• W2094658637 hasConcept C526805850 @default.
• W2094658637 hasConcept C55493867 @default.
• W2094658637 hasConcept C64927066 @default.
• W2094658637 hasConcept C71924100 @default.
• W2094658637 hasConcept C86803240 @default.
• W2094658637 hasConcept C98274493 @default.
• W2094658637 hasConceptScore W2094658637C104317684 @default.
• W2094658637 hasConceptScore W2094658637C121608353 @default.
• W2094658637 hasConceptScore W2094658637C126322002 @default.
• W2094658637 hasConceptScore W2094658637C143998085 @default.
• W2094658637 hasConceptScore W2094658637C2776256026 @default.
• W2094658637 hasConceptScore W2094658637C2776694085 @default.
• W2094658637 hasConceptScore W2094658637C2776999253 @default.
• W2094658637 hasConceptScore W2094658637C2777240266 @default.
• W2094658637 hasConceptScore W2094658637C2777292972 @default.
• W2094658637 hasConceptScore W2094658637C2778239845 @default.
• W2094658637 hasConceptScore W2094658637C2778305200 @default.
• W2094658637 hasConceptScore W2094658637C2780259306 @default.
• W2094658637 hasConceptScore W2094658637C2780350996 @default.
• W2094658637 hasConceptScore W2094658637C2781190966 @default.
• W2094658637 hasConceptScore W2094658637C2781451048 @default.
• W2094658637 hasConceptScore W2094658637C502942594 @default.
• W2094658637 hasConceptScore W2094658637C526805850 @default.
• W2094658637 hasConceptScore W2094658637C55493867 @default.
• W2094658637 hasConceptScore W2094658637C64927066 @default.
• W2094658637 hasConceptScore W2094658637C71924100 @default.
• W2094658637 hasConceptScore W2094658637C86803240 @default.
• W2094658637 hasConceptScore W2094658637C98274493 @default.
• W2094658637 hasLocation W20946586371 @default.
• W2094658637 hasLocation W20946586372 @default.
• W2094658637 hasOpenAccess W2094658637 @default.
• W2094658637 hasPrimaryLocation W20946586371 @default.
• W2094658637 hasRelatedWork W1827802461 @default.
• W2094658637 hasRelatedWork W2006068954 @default.
• W2094658637 hasRelatedWork W2007479878 @default.
• W2094658637 hasRelatedWork W2038269141 @default.
• W2094658637 hasRelatedWork W2053305649 @default.
• W2094658637 hasRelatedWork W2059363555 @default.
• W2094658637 hasRelatedWork W2061036056 @default.
• W2094658637 hasRelatedWork W2080695455 @default.
• W2094658637 hasRelatedWork W2105906697 @default.
• W2094658637 hasRelatedWork W2132880072 @default.
• W2094658637 hasRelatedWork W2146399575 @default.

• next