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- W2094659968 abstract "Transformation of Streptomyces galilaeus ATCC 31133 with the aklavinone 11-hydroxylase gene (dnrF) resulted in the production of many red pigments. The new metabolites were purified and their structures were determined as 11-hydroxylated aclacinomycin A, B and T by spectral analysis. This result indicated that the dnrF was stably expressed in the strain S. galilaeus ATCC 31133 to give rise to hybrid aclacinomycins. In addition, a new aclacinomycin analog named 11-hydroxyaclacinomycin X was isolated from the same culture. Its structure was elucidated as 2'''-amino-11-hydroxyaclacinomycin Y. It showed strong cytotoxicity against several human tumor cell lines, especially leukemia and melanoma cell lines." @default.
- W2094659968 created "2016-06-24" @default.
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- W2094659968 date "1996-01-01" @default.
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- W2094659968 title "New Anthracycline Metabolites Produced by the Aklavinone 11-Hydroxylase Gene in Streptomyces galilaeus ATCC 31133." @default.
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- W2094659968 doi "https://doi.org/10.7164/antibiotics.49.355" @default.
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