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• W2094668617 abstract "A pancreatic deoxyribonuclease preparation, shown to be free of significant ribonuclease activity, inhibits hemoglobin synthesis in a rabbit reticulocyte lysate. Preincubation with DNAase (15 min at 25°C) is required to obtain a marked inhibitory effect (nearly 70%). It has been shown that DNAase does not significantly interfere with the elongation or termination steps of translation, but it seems to prevent reinitiation of globin polypeptide chains allowing polysome run-off. In particular, the formation of the 40Smet-tRNAmetf complex is greatly reduced in the DNAase-treated lysate. At the moment the mechanism by which DNAase inhibits initiation is not clear." @default.
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• W2094668617 date "1975-12-01" @default.
• W2094668617 modified "2023-09-24" @default.
• W2094668617 title "Inhibition of hemoglobin synthesis by pancreatic deoxyribonuclease in rabbit reticulocyte lysates" @default.
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• W2094668617 doi "https://doi.org/10.1016/0005-2787(75)90217-8" @default.
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