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• W2094673949 abstract "Design, synthesis and structure–activity relationships of benzimidazole derivatives as activators of the AMP-activated protein kinase (AMPK) are presented in this paper. AMPK is the central component of a protein kinase cascade that plays a key role in the regulation of energy balance. Once activated, AMPK initiates a series of responses that are aimed at restoring the energy balance of the cell and recent studies have indicated that AMPK plays an important role in regulation of the whole-body energy metabolism. The following study based on the lead compound S27847 involved modification of three regions of this compound. Preliminary structure–activity relationships are being described." @default.
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• W2094673949 date "2006-07-01" @default.
• W2094673949 modified "2023-09-25" @default.
• W2094673949 title "Synthesis and biological evaluation of benzimidazole derivatives as potent AMP-activated protein kinase activators" @default.
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• W2094673949 doi "https://doi.org/10.1016/j.bmc.2006.02.028" @default.
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